Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation
Acylpeptide hydrolase (APEH), one of the four members of the prolyl oligopeptidase class, catalyses the removal of N-acylated amino acids from acetylated peptides and it has been postulated to play a key role in protein degradation machinery. Disruption of protein turnover has been established as an...
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| Format: | Online |
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Public Library of Science
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189933/ |
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pubmed-3189933 |
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pubmed-31899332011-10-20 Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation Palmieri, Gianna Bergamo, Paolo Luini, Alberto Ruvo, Menotti Gogliettino, Marta Langella, Emma Saviano, Michele Hegde, Ramanath N. Sandomenico, Annamaria Rossi, Mose Research Article Acylpeptide hydrolase (APEH), one of the four members of the prolyl oligopeptidase class, catalyses the removal of N-acylated amino acids from acetylated peptides and it has been postulated to play a key role in protein degradation machinery. Disruption of protein turnover has been established as an effective strategy to down-regulate the ubiquitin-proteasome system (UPS) and as a promising approach in anticancer therapy. Public Library of Science 2011-10-10 /pmc/articles/PMC3189933/ /pubmed/22016782 http://dx.doi.org/10.1371/journal.pone.0025888 Text en Palmieri et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Palmieri, Gianna Bergamo, Paolo Luini, Alberto Ruvo, Menotti Gogliettino, Marta Langella, Emma Saviano, Michele Hegde, Ramanath N. Sandomenico, Annamaria Rossi, Mose |
| spellingShingle |
Palmieri, Gianna Bergamo, Paolo Luini, Alberto Ruvo, Menotti Gogliettino, Marta Langella, Emma Saviano, Michele Hegde, Ramanath N. Sandomenico, Annamaria Rossi, Mose Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation |
| author_facet |
Palmieri, Gianna Bergamo, Paolo Luini, Alberto Ruvo, Menotti Gogliettino, Marta Langella, Emma Saviano, Michele Hegde, Ramanath N. Sandomenico, Annamaria Rossi, Mose |
| author_sort |
Palmieri, Gianna |
| title |
Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation |
| title_short |
Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation |
| title_full |
Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation |
| title_fullStr |
Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation |
| title_full_unstemmed |
Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation |
| title_sort |
acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation |
| description |
Acylpeptide hydrolase (APEH), one of the four members of the prolyl oligopeptidase class, catalyses the removal of N-acylated amino acids from acetylated peptides and it has been postulated to play a key role in protein degradation machinery. Disruption of protein turnover has been established as an effective strategy to down-regulate the ubiquitin-proteasome system (UPS) and as a promising approach in anticancer therapy. |
| publisher |
Public Library of Science |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189933/ |
| _version_ |
1611479835873378304 |