Predicting P-Glycoprotein-Mediated Drug Transport Based On Support Vector Machine and Three-Dimensional Crystal Structure of P-glycoprotein

Predicting P-Glycoprotein-Mediated Drug Transport Based On Support Vector Machine and Three-Dimensional Crystal Structure of P-glycoprotein

Human P-glycoprotein (P-gp) is an ATP-binding cassette multidrug transporter that confers resistance to a wide range of chemotherapeutic agents in cancer cells by active efflux of the drugs from cells. P-gp also plays a key role in limiting oral absorption and brain penetration and in facilitating b...

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Bibliographic Details
Main Authors: Bikadi, Zsolt, Hazai, Istvan, Malik, David, Jemnitz, Katalin, Veres, Zsuzsa, Hari, Peter, Ni, Zhanglin, Loo, Tip W., Clarke, David M., Hazai, Eszter, Mao, Qingcheng
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186768/

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