Glycosphingolipids as Receptors for Non-Enveloped Viruses
Glycosphingolipids are ubiquitous molecules composed of a lipid and a carbohydrate moiety. Their main functions are as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation of signal transduction pathways. Microbes take advantage of the different carbohydrate stru...
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Molecular Diversity Preservation International (MDPI)
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185660/ |
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pubmed-31856602011-10-12 Glycosphingolipids as Receptors for Non-Enveloped Viruses Taube, Stefan Jiang, Mengxi Wobus, Christiane E. Review Glycosphingolipids are ubiquitous molecules composed of a lipid and a carbohydrate moiety. Their main functions are as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation of signal transduction pathways. Microbes take advantage of the different carbohydrate structures displayed on a specific cell surface for attachment during infection. For some viruses, such as the polyomaviruses, binding to gangliosides determines the internalization pathway into cells. For others, the interaction between microbe and carbohydrate can be a critical determinant for host susceptibility. In this review, we summarize the role of glycosphingolipids as receptors for members of the non-enveloped calici-, rota-, polyoma- and parvovirus families. Molecular Diversity Preservation International (MDPI) 2010-04-15 /pmc/articles/PMC3185660/ /pubmed/21994669 http://dx.doi.org/10.3390/v2041011 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Taube, Stefan Jiang, Mengxi Wobus, Christiane E. |
| spellingShingle |
Taube, Stefan Jiang, Mengxi Wobus, Christiane E. Glycosphingolipids as Receptors for Non-Enveloped Viruses |
| author_facet |
Taube, Stefan Jiang, Mengxi Wobus, Christiane E. |
| author_sort |
Taube, Stefan |
| title |
Glycosphingolipids as Receptors for Non-Enveloped Viruses |
| title_short |
Glycosphingolipids as Receptors for Non-Enveloped Viruses |
| title_full |
Glycosphingolipids as Receptors for Non-Enveloped Viruses |
| title_fullStr |
Glycosphingolipids as Receptors for Non-Enveloped Viruses |
| title_full_unstemmed |
Glycosphingolipids as Receptors for Non-Enveloped Viruses |
| title_sort |
glycosphingolipids as receptors for non-enveloped viruses |
| description |
Glycosphingolipids are ubiquitous molecules composed of a lipid and a carbohydrate moiety. Their main functions are as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation of signal transduction pathways. Microbes take advantage of the different carbohydrate structures displayed on a specific cell surface for attachment during infection. For some viruses, such as the polyomaviruses, binding to gangliosides determines the internalization pathway into cells. For others, the interaction between microbe and carbohydrate can be a critical determinant for host susceptibility. In this review, we summarize the role of glycosphingolipids as receptors for members of the non-enveloped calici-, rota-, polyoma- and parvovirus families. |
| publisher |
Molecular Diversity Preservation International (MDPI) |
| publishDate |
2010 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185660/ |
| _version_ |
1611479091484033024 |