Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection

The natural history of hepatitis C virus (HCV) infection is determined by a complex interplay between host genetic, immunological and viral factors. This review highlights genes involved in innate and adaptive immune responses associated with different outcomes of HCV infection. For example, an asso...

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Main Authors:	Bengsch, Bertram, Thimme, Robert, Blum, Hubert E.
Format:	Online
Language:	English
Published:	Molecular Diversity Preservation International (MDPI) 2009
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185494/

id	pubmed-3185494
recordtype	oai_dc
spelling	pubmed-31854942011-10-12 Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection Bengsch, Bertram Thimme, Robert Blum, Hubert E. Review The natural history of hepatitis C virus (HCV) infection is determined by a complex interplay between host genetic, immunological and viral factors. This review highlights genes involved in innate and adaptive immune responses associated with different outcomes of HCV infection. For example, an association of HCV clearance with certain HLA alleles has been demonstrated. The mechanisms responsible for these associations have been linked to specific T cell responses for some particular alleles (e.g., HLA-B27). Genetic associations involved in T cell regulation and function further underline the role of the adaptive immune response in the natural history of HCV infection. In addition, some genes involved in innate NK cell responses demonstrate the complex interplay between components of the immune system necessary for a successful host response to HCV infection. Molecular Diversity Preservation International (MDPI) 2009-08-05 /pmc/articles/PMC3185494/ /pubmed/21994541 http://dx.doi.org/10.3390/v1020104 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bengsch, Bertram Thimme, Robert Blum, Hubert E.
spellingShingle	Bengsch, Bertram Thimme, Robert Blum, Hubert E. Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection
author_facet	Bengsch, Bertram Thimme, Robert Blum, Hubert E.
author_sort	Bengsch, Bertram
title	Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection
title_short	Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection
title_full	Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection
title_fullStr	Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection
title_full_unstemmed	Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection
title_sort	role of host genetic factors in the outcome of hepatitis c virus infection
description	The natural history of hepatitis C virus (HCV) infection is determined by a complex interplay between host genetic, immunological and viral factors. This review highlights genes involved in innate and adaptive immune responses associated with different outcomes of HCV infection. For example, an association of HCV clearance with certain HLA alleles has been demonstrated. The mechanisms responsible for these associations have been linked to specific T cell responses for some particular alleles (e.g., HLA-B27). Genetic associations involved in T cell regulation and function further underline the role of the adaptive immune response in the natural history of HCV infection. In addition, some genes involved in innate NK cell responses demonstrate the complex interplay between components of the immune system necessary for a successful host response to HCV infection.
publisher	Molecular Diversity Preservation International (MDPI)
publishDate	2009
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185494/
_version_	1611479015625850880

Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection

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