Treatment of an Intramammary Bacterial Infection with 25-Hydroxyvitamin D3

Deficiency of serum levels of 25-hydroxyvitamin D3 has been correlated with increased risk of infectious diseases such as tuberculosis and influenza. A plausible reason for this association is that expression of genes encoding important antimicrobial proteins depends on concentrations of 1,25-dihydr...

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Main Authors:	Lippolis, John D., Reinhardt, Timothy A., Sacco, Randy A., Nonnecke, Brian J., Nelson, Corwin D.
Format:	Online
Language:	English
Published:	Public Library of Science 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184989/

id	pubmed-3184989
recordtype	oai_dc
spelling	pubmed-31849892011-10-11 Treatment of an Intramammary Bacterial Infection with 25-Hydroxyvitamin D3 Lippolis, John D. Reinhardt, Timothy A. Sacco, Randy A. Nonnecke, Brian J. Nelson, Corwin D. Research Article Deficiency of serum levels of 25-hydroxyvitamin D3 has been correlated with increased risk of infectious diseases such as tuberculosis and influenza. A plausible reason for this association is that expression of genes encoding important antimicrobial proteins depends on concentrations of 1,25-dihydroxyvitamin D3 produced by activated immune cells at sites of infection, and that synthesis of 1,25-dihydroxyvitamin D3 is dependent on the availability of 25-hydroxyvitamin D3. Thus, increasing the availability of 25(OH)D3 for immune cell synthesis of 1,25-dihydroxyvitamin D3 at sites of infection has been hypothesized to aid in clearance of the infection. This report details the treatment of an acute intramammary infection with infusion of 25-hydroxyvitamin D3 to the site of infection. Ten lactating cows were infected with in one quarter of their mammary glands. Half of the animals were treated intramammary with 25-hydroxyvitamin D3. The 25-hydroxyvitamin D3 treated animal showed significantly lower bacterial counts in milk and showed reduced symptomatic affects of the mastitis. It is significant that treatment with 25-hydroxyvitamin D3 reduced the severity of an acute bacterial infection. This finding suggested a significant non-antibiotic complimentary role for 25-hydroxyvitamin D3 in the treatment of infections in compartments naturally low in 25-hydroxyvitamin D3 such as the mammary gland and by extension, possibly upper respiratory tract infections. Public Library of Science 2011-10-03 /pmc/articles/PMC3184989/ /pubmed/21991312 http://dx.doi.org/10.1371/journal.pone.0025479 Text en This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lippolis, John D. Reinhardt, Timothy A. Sacco, Randy A. Nonnecke, Brian J. Nelson, Corwin D.
spellingShingle	Lippolis, John D. Reinhardt, Timothy A. Sacco, Randy A. Nonnecke, Brian J. Nelson, Corwin D. Treatment of an Intramammary Bacterial Infection with 25-Hydroxyvitamin D3
author_facet	Lippolis, John D. Reinhardt, Timothy A. Sacco, Randy A. Nonnecke, Brian J. Nelson, Corwin D.
author_sort	Lippolis, John D.
title	Treatment of an Intramammary Bacterial Infection with 25-Hydroxyvitamin D3
title_short	Treatment of an Intramammary Bacterial Infection with 25-Hydroxyvitamin D3
title_full	Treatment of an Intramammary Bacterial Infection with 25-Hydroxyvitamin D3
title_fullStr	Treatment of an Intramammary Bacterial Infection with 25-Hydroxyvitamin D3
title_full_unstemmed	Treatment of an Intramammary Bacterial Infection with 25-Hydroxyvitamin D3
title_sort	treatment of an intramammary bacterial infection with 25-hydroxyvitamin d3
description	Deficiency of serum levels of 25-hydroxyvitamin D3 has been correlated with increased risk of infectious diseases such as tuberculosis and influenza. A plausible reason for this association is that expression of genes encoding important antimicrobial proteins depends on concentrations of 1,25-dihydroxyvitamin D3 produced by activated immune cells at sites of infection, and that synthesis of 1,25-dihydroxyvitamin D3 is dependent on the availability of 25-hydroxyvitamin D3. Thus, increasing the availability of 25(OH)D3 for immune cell synthesis of 1,25-dihydroxyvitamin D3 at sites of infection has been hypothesized to aid in clearance of the infection. This report details the treatment of an acute intramammary infection with infusion of 25-hydroxyvitamin D3 to the site of infection. Ten lactating cows were infected with in one quarter of their mammary glands. Half of the animals were treated intramammary with 25-hydroxyvitamin D3. The 25-hydroxyvitamin D3 treated animal showed significantly lower bacterial counts in milk and showed reduced symptomatic affects of the mastitis. It is significant that treatment with 25-hydroxyvitamin D3 reduced the severity of an acute bacterial infection. This finding suggested a significant non-antibiotic complimentary role for 25-hydroxyvitamin D3 in the treatment of infections in compartments naturally low in 25-hydroxyvitamin D3 such as the mammary gland and by extension, possibly upper respiratory tract infections.
publisher	Public Library of Science
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184989/
_version_	1611478893253885952

Treatment of an Intramammary Bacterial Infection with 25-Hydroxyvitamin D3

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