Inhibition of PI3K Prevents the Proliferation and Differentiation of Human Lung Fibroblasts into Myofibroblasts: The Role of Class I P110 Isoforms

Inhibition of PI3K Prevents the Proliferation and Differentiation of Human Lung Fibroblasts into Myofibroblasts: The Role of Class I P110 Isoforms

Idiopathic pulmonary fibrosis (IPF) is a progressive fibroproliferative disease characterized by an accumulation of fibroblasts and myofibroblasts in the alveolar wall. Even though the pathogenesis of this fatal disorder remains unclear, transforming growth factor-β (TGF-β)-induced differentiation a...

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Bibliographic Details
Main Authors: Conte, Enrico, Fruciano, Mary, Fagone, Evelina, Gili, Elisa, Caraci, Filippo, Iemmolo, Maria, Crimi, Nunzio, Vancheri, Carlo
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184941/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184941/

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