Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome
Role of resistin in insulin sensitivity and metabolic syndrome (MetS) is controversial till date. Increased serum resistin levels are associated with MetS and insulin resistance. The aim of this study was to investigate the relationship between serum resistin levels with markers of the MetS in femal...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Medknow Publications Pvt Ltd
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183627/ |
| id |
pubmed-3183627 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-31836272011-10-04 Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome Gupta, V. Singh, A. K. Gupta, Vani Kumar, S. Srivastava, N. Jafar, T. Pant, A. B. Original Article Role of resistin in insulin sensitivity and metabolic syndrome (MetS) is controversial till date. Increased serum resistin levels are associated with MetS and insulin resistance. The aim of this study was to investigate the relationship between serum resistin levels with markers of the MetS in females. In a cross-sectional study, a total of 170 healthy female subjects were selected for the study. Out of which 71 (age 31.59 ± 4.88 years) were with MetS and 99 (age 31.75 ± 6.34 years) were without MetS. Different parameters of MetS and serum resistin level were measured according to the standard protocols as given in NCEP ATP III 2001 guideline. Serum resistin levels were significantly higher in subjects with MetS when compared with subjects without MetS [13.54 ± 4.14 ng/ml (n = 71) vs. 7.42 ± 2.31 ng/ml (n = 99); P ≤ 0.001]. Resistin levels were positively associated with waist circumference, systolic and diastolic blood pressure, plasma glucose, waist/hip ratio, serum triglycerides, serum cholesterol, serum VLDL, plasma insulin, and insulin resistance, while it was negatively associated with high-density lipoprotein. This study demonstrates a positive correlation between resistin and factors of MetS except high-density lipoprotein which was found to be negatively correlated in Indian female subjects. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3183627/ /pubmed/21976825 http://dx.doi.org/10.4103/0971-6580.84272 Text en © Toxicology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Gupta, V. Singh, A. K. Gupta, Vani Kumar, S. Srivastava, N. Jafar, T. Pant, A. B. |
| spellingShingle |
Gupta, V. Singh, A. K. Gupta, Vani Kumar, S. Srivastava, N. Jafar, T. Pant, A. B. Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome |
| author_facet |
Gupta, V. Singh, A. K. Gupta, Vani Kumar, S. Srivastava, N. Jafar, T. Pant, A. B. |
| author_sort |
Gupta, V. |
| title |
Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome |
| title_short |
Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome |
| title_full |
Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome |
| title_fullStr |
Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome |
| title_full_unstemmed |
Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome |
| title_sort |
association of circulating resistin with metabolic risk factors in indian females having metabolic syndrome |
| description |
Role of resistin in insulin sensitivity and metabolic syndrome (MetS) is controversial till date. Increased serum resistin levels are associated with MetS and insulin resistance. The aim of this study was to investigate the relationship between serum resistin levels with markers of the MetS in females. In a cross-sectional study, a total of 170 healthy female subjects were selected for the study. Out of which 71 (age 31.59 ± 4.88 years) were with MetS and 99 (age 31.75 ± 6.34 years) were without MetS. Different parameters of MetS and serum resistin level were measured according to the standard protocols as given in NCEP ATP III 2001 guideline. Serum resistin levels were significantly higher in subjects with MetS when compared with subjects without MetS [13.54 ± 4.14 ng/ml (n = 71) vs. 7.42 ± 2.31 ng/ml (n = 99); P ≤ 0.001]. Resistin levels were positively associated with waist circumference, systolic and diastolic blood pressure, plasma glucose, waist/hip ratio, serum triglycerides, serum cholesterol, serum VLDL, plasma insulin, and insulin resistance, while it was negatively associated with high-density lipoprotein. This study demonstrates a positive correlation between resistin and factors of MetS except high-density lipoprotein which was found to be negatively correlated in Indian female subjects. |
| publisher |
Medknow Publications Pvt Ltd |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183627/ |
| _version_ |
1611478495368577024 |