The Haploinsufficient Hematopoietic Microenvironment Is Critical to the Pathological Fracture Repair in Murine Models of Neurofibromatosis Type 1

The Haploinsufficient Hematopoietic Microenvironment Is Critical to the Pathological Fracture Repair in Murine Models of Neurofibromatosis Type 1

Germline mutations in the NF1 tumor suppressor gene cause neurofibromatosis type 1 (NF1), a complex genetic disorder with a high predisposition of numerous skeletal dysplasias including short stature, osteoporosis, kyphoscoliosis, and fracture non-union (pseudoarthrosis). We have developed murine mo...

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Bibliographic Details
Main Authors: Wu, Xiaohua, Chen, Shi, He, Yongzheng, Rhodes, Steven D., Mohammad, Khalid S., Li, Xiaohong, Yang, Xianlin, Jiang, Li, Nalepa, Grzegorz, Snider, Paige, Robling, Alexander G., Clapp, D. Wade, Conway, Simon J., Guise, Theresa A., Yang, Feng-Chun
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182976/

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