CB2 Cannabinoid Receptor Targets Mitogenic Gi Protein–Cyclin D1 Axis in Osteoblasts

CB2 Cannabinoid Receptor Targets Mitogenic Gi Protein–Cyclin D1 Axis in Osteoblasts

CB2 is a Gi protein–coupled receptor activated by endo- and phytocannabinoids, thus inhibiting stimulated adenylyl cyclase activity. CB2 is expressed in bone cells and Cb2 null mice show a marked age-related bone loss. CB2-specific agonists both attenuate and rescue ovariectomy-induced bone loss. Ac...

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Bibliographic Details
Main Authors: Ofek, Orr, Attar-Namdar, Malka, Kram, Vardit, Dvir-Ginzberg, Mona, Mechoulam, Raphael, Zimmer, Andreas, Frenkel, Baruch, Shohami, Esther, Bab, Itai
Format: Online
Language:English
Published: Wiley Subscription Services, Inc., A Wiley Company 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179350/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179350/

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