Structural Chemistry of Human SET Domain Protein Methyltransferases
There are about fifty SET domain protein methyltransferases (PMTs) in the human genome, that transfer a methyl group from S-adenosyl-L-methionine (SAM) to substrate lysines on histone tails or other peptides. A number of structures in complex with cofactor, substrate, or inhibitors revealed the mech...
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| Format: | Online |
| Language: | English |
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Bentham Open
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178901/ |