Unrepairable DNA Double Strand Breaks Initiate Cytotoxicity with HSV-TK/Ganciclovir
The herpes simplex virus thymidine kinase (HSV-TK) is the most widely used suicide gene in cancer gene therapy due to its superior anticancer activity with ganciclovir compared to other HSV-TK substrates, such as 1-β-D-arabinofuranosyl thymine (araT). We have evaluated the role of DNA damage as a me...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176965/ |