Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations

Pancreatic islet transplantation is a promising option for the treatment of type 1 diabetic patients. After the successful demonstration of the Edmonton protocol, islet transplantation has advanced significantly on several fronts, including improved pancreas procurement and preservation systems. Sin...

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Main Author:	Noguchi, Hirofumi
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171759/

id	pubmed-3171759
recordtype	oai_dc
spelling	pubmed-31717592011-09-14 Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations Noguchi, Hirofumi Review Article Pancreatic islet transplantation is a promising option for the treatment of type 1 diabetic patients. After the successful demonstration of the Edmonton protocol, islet transplantation has advanced significantly on several fronts, including improved pancreas procurement and preservation systems. Since we frequently use pancreata from donors after cardiac death in Japan,we have applied the in situ regional organ cooling system for pancreas procurement to reduce the warm ischemic time. To reduce the apoptosis of pancreatic tissue during cold preservation, we have applied the ductal injection of preservation solution. For pancreas preservation, we use modified Kyoto solution, which is advantageous at trypsin inhibition and less collagenase inhibition. In this paper, we show pancreas procurement and preservation in our group for islet transplantation. Hindawi Publishing Corporation 2011 2011-09-12 /pmc/articles/PMC3171759/ /pubmed/21918716 http://dx.doi.org/10.1155/2011/783168 Text en Copyright © 2011 Hirofumi Noguchi. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Noguchi, Hirofumi
spellingShingle	Noguchi, Hirofumi Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations
author_facet	Noguchi, Hirofumi
author_sort	Noguchi, Hirofumi
title	Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations
title_short	Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations
title_full	Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations
title_fullStr	Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations
title_full_unstemmed	Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations
title_sort	pancreas procurement and preservation for islet transplantation: personal considerations
description	Pancreatic islet transplantation is a promising option for the treatment of type 1 diabetic patients. After the successful demonstration of the Edmonton protocol, islet transplantation has advanced significantly on several fronts, including improved pancreas procurement and preservation systems. Since we frequently use pancreata from donors after cardiac death in Japan,we have applied the in situ regional organ cooling system for pancreas procurement to reduce the warm ischemic time. To reduce the apoptosis of pancreatic tissue during cold preservation, we have applied the ductal injection of preservation solution. For pancreas preservation, we use modified Kyoto solution, which is advantageous at trypsin inhibition and less collagenase inhibition. In this paper, we show pancreas procurement and preservation in our group for islet transplantation.
publisher	Hindawi Publishing Corporation
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171759/
_version_	1611475264656637952

Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations

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