Genomic Architecture of Aggression: Rare Copy Number Variants in Intermittent Explosive Disorder
Copy number variants (CNVs) are known to be associated with complex neuropsychiatric disorders (e.g., schizophrenia and autism) but have not been explored in the isolated features of aggressive behaviors such as intermittent explosive disorder (IED). IED is characterized by recurrent episodes of agg...
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Wiley Subscription Services, Inc., A Wiley Company
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168586/ |
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pubmed-31685862012-06-01 Genomic Architecture of Aggression: Rare Copy Number Variants in Intermittent Explosive Disorder Vu, Tiffany H Coccaro, Emil F Eichler, Evan E Girirajan, Santhosh Research Articles Copy number variants (CNVs) are known to be associated with complex neuropsychiatric disorders (e.g., schizophrenia and autism) but have not been explored in the isolated features of aggressive behaviors such as intermittent explosive disorder (IED). IED is characterized by recurrent episodes of aggression in which individuals act impulsively and grossly out of proportion from the involved stressors. Previous studies have identified genetic variants in the serotonergic pathway that play a role in susceptibility to this behavior, but additional contributors have not been identified. Therefore, to further delineate possible genetic influences, we investigated CNVs in individuals diagnosed with IED and/or personality disorder (PD). We carried out array comparative genomic hybridization on 113 samples of individuals with isolated features of IED (n = 90) or PD (n = 23). We detected a recurrent 1.35-Mbp deletion on chromosome 1q21.1 in one IED subject and a novel ∼350-kbp deletion on chromosome 16q22.3q23.1 in another IED subject. While five recent reports have suggested the involvement of an ∼1.6-Mbp 15q13.3 deletion in individuals with behavioral problems, particularly aggression, we report an absence of such events in our study of individuals specifically selected for aggression. We did, however, detect a smaller ∼430-kbp 15q13.3 duplication containing CHRNA7 in one individual with PD. While these results suggest a possible role for rare CNVs in identifying genes underlying IED or PD, further studies on a large number of well-characterized individuals are necessary. © 2011 Wiley-Liss, Inc. Wiley Subscription Services, Inc., A Wiley Company 2011-12 2011-08-02 /pmc/articles/PMC3168586/ /pubmed/21812102 http://dx.doi.org/10.1002/ajmg.b.31225 Text en Copyright © 2011 Wiley-Liss, Inc. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Vu, Tiffany H Coccaro, Emil F Eichler, Evan E Girirajan, Santhosh |
| spellingShingle |
Vu, Tiffany H Coccaro, Emil F Eichler, Evan E Girirajan, Santhosh Genomic Architecture of Aggression: Rare Copy Number Variants in Intermittent Explosive Disorder |
| author_facet |
Vu, Tiffany H Coccaro, Emil F Eichler, Evan E Girirajan, Santhosh |
| author_sort |
Vu, Tiffany H |
| title |
Genomic Architecture of Aggression: Rare Copy Number Variants in Intermittent Explosive Disorder |
| title_short |
Genomic Architecture of Aggression: Rare Copy Number Variants in Intermittent Explosive Disorder |
| title_full |
Genomic Architecture of Aggression: Rare Copy Number Variants in Intermittent Explosive Disorder |
| title_fullStr |
Genomic Architecture of Aggression: Rare Copy Number Variants in Intermittent Explosive Disorder |
| title_full_unstemmed |
Genomic Architecture of Aggression: Rare Copy Number Variants in Intermittent Explosive Disorder |
| title_sort |
genomic architecture of aggression: rare copy number variants in intermittent explosive disorder |
| description |
Copy number variants (CNVs) are known to be associated with complex neuropsychiatric disorders (e.g., schizophrenia and autism) but have not been explored in the isolated features of aggressive behaviors such as intermittent explosive disorder (IED). IED is characterized by recurrent episodes of aggression in which individuals act impulsively and grossly out of proportion from the involved stressors. Previous studies have identified genetic variants in the serotonergic pathway that play a role in susceptibility to this behavior, but additional contributors have not been identified. Therefore, to further delineate possible genetic influences, we investigated CNVs in individuals diagnosed with IED and/or personality disorder (PD). We carried out array comparative genomic hybridization on 113 samples of individuals with isolated features of IED (n = 90) or PD (n = 23). We detected a recurrent 1.35-Mbp deletion on chromosome 1q21.1 in one IED subject and a novel ∼350-kbp deletion on chromosome 16q22.3q23.1 in another IED subject. While five recent reports have suggested the involvement of an ∼1.6-Mbp 15q13.3 deletion in individuals with behavioral problems, particularly aggression, we report an absence of such events in our study of individuals specifically selected for aggression. We did, however, detect a smaller ∼430-kbp 15q13.3 duplication containing CHRNA7 in one individual with PD. While these results suggest a possible role for rare CNVs in identifying genes underlying IED or PD, further studies on a large number of well-characterized individuals are necessary. © 2011 Wiley-Liss, Inc. |
| publisher |
Wiley Subscription Services, Inc., A Wiley Company |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168586/ |
| _version_ |
1611474272924991488 |