Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia

Multifunctional scaffolding protein beta-arrestins (βArr) and the G protein-receptor kinases are involved in the desensitization of several G protein-coupled receptors (GPCR). However, arrestins can also contribute to GPCR signaling independently from G proteins. In this review, we focus on the role...

Full description

Bibliographic Details
Main Authors:	Del’Guidice, Thomas, Lemasson, Morgane, Beaulieu, Jean-Martin
Format:	Online
Language:	English
Published:	Frontiers Research Foundation 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167352/

id	pubmed-3167352
recordtype	oai_dc
spelling	pubmed-31673522011-09-15 Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia Del’Guidice, Thomas Lemasson, Morgane Beaulieu, Jean-Martin Neuroscience Multifunctional scaffolding protein beta-arrestins (βArr) and the G protein-receptor kinases are involved in the desensitization of several G protein-coupled receptors (GPCR). However, arrestins can also contribute to GPCR signaling independently from G proteins. In this review, we focus on the role of βArr in the regulation of dopamine receptor functions in the striatum. First, we present in vivo evidence supporting a role for these proteins in the regulation of dopamine receptor desensitization. Second, we provide an overview of the roles of βArr2 in the regulation of extracellular-signal-regulated kinases/MAP kinases and Akt/GSK3 signaling pathways downstream of the D1 and D2 dopamine receptors. Thereafter, we examine the possible involvement of βArr-mediated signaling in the action of dopaminergic drugs used for the treatment of mental disorders. Finally, we focus on different potential cellular proteins regulated by βArr-mediated signaling which could contribute to the regulation of behavioral responses to dopamine. Overall, the identification of a cell signaling function for βArr downstream of dopamine receptors underscores the intricate complexity of the intertwined mechanisms regulating and mediating cell signaling in the basal ganglia. Understanding these mechanisms may lead to a better comprehension of the several roles played by these structures in the regulation of mood and to the development of new psychoactive drugs having better therapeutic efficacy. Frontiers Research Foundation 2011-09-06 /pmc/articles/PMC3167352/ /pubmed/21922001 http://dx.doi.org/10.3389/fnana.2011.00058 Text en Copyright © 2011 Del’Guidice, Lemasson and Beaulieu. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Del’Guidice, Thomas Lemasson, Morgane Beaulieu, Jean-Martin
spellingShingle	Del’Guidice, Thomas Lemasson, Morgane Beaulieu, Jean-Martin Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia
author_facet	Del’Guidice, Thomas Lemasson, Morgane Beaulieu, Jean-Martin
author_sort	Del’Guidice, Thomas
title	Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia
title_short	Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia
title_full	Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia
title_fullStr	Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia
title_full_unstemmed	Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia
title_sort	role of beta-arrestin 2 downstream of dopamine receptors in the basal ganglia
description	Multifunctional scaffolding protein beta-arrestins (βArr) and the G protein-receptor kinases are involved in the desensitization of several G protein-coupled receptors (GPCR). However, arrestins can also contribute to GPCR signaling independently from G proteins. In this review, we focus on the role of βArr in the regulation of dopamine receptor functions in the striatum. First, we present in vivo evidence supporting a role for these proteins in the regulation of dopamine receptor desensitization. Second, we provide an overview of the roles of βArr2 in the regulation of extracellular-signal-regulated kinases/MAP kinases and Akt/GSK3 signaling pathways downstream of the D1 and D2 dopamine receptors. Thereafter, we examine the possible involvement of βArr-mediated signaling in the action of dopaminergic drugs used for the treatment of mental disorders. Finally, we focus on different potential cellular proteins regulated by βArr-mediated signaling which could contribute to the regulation of behavioral responses to dopamine. Overall, the identification of a cell signaling function for βArr downstream of dopamine receptors underscores the intricate complexity of the intertwined mechanisms regulating and mediating cell signaling in the basal ganglia. Understanding these mechanisms may lead to a better comprehension of the several roles played by these structures in the regulation of mood and to the development of new psychoactive drugs having better therapeutic efficacy.
publisher	Frontiers Research Foundation
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167352/
_version_	1611473820431941632

Role of Beta-Arrestin 2 Downstream of Dopamine Receptors in the Basal Ganglia

Similar Items