Imaging Long-Term Fate of Intramyocardially Implanted Mesenchymal Stem Cells in a Porcine Myocardial Infarction Model

Imaging Long-Term Fate of Intramyocardially Implanted Mesenchymal Stem Cells in a Porcine Myocardial Infarction Model

The long-term fate of stem cells after intramyocardial delivery is unknown. We used noninvasive, repetitive PET/CT imaging with [18F]FEAU to monitor the long-term (up to 5 months) spatial-temporal dynamics of MSCs retrovirally transduced with the sr39HSV1-tk gene (sr39HSV1-tk-MSC) and implanted intr...

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Main Authors: Perin, Emerson C., Tian, Mei, Marini, Frank C., Silva, Guilherme V., Zheng, Yi, Baimbridge, Fred, Quan, Xin, Fernandes, Marlos R., Gahremanpour, Amir, Young, Daniel, Paolillo, Vincenzo, Mukhopadhyay, Uday, Borne, Agatha T., Uthamanthil, Rajesh, Brammer, David, Jackson, James, Decker, William K., Najjar, Amer M., Thomas, Michael W., Volgin, Andrei, Rabinovich, Brian, Soghomonyan, Suren, Jeong, Hwan-Jeong, Rios, Jesse M., Steiner, David, Robinson, Simon, Mawlawi, Osama, Pan, Tinsu, Stafford, Jason, Kundra, Vikas, Li, Chun, Alauddin, Mian M., Willerson, James T., Shpall, Elizabeth, Gelovani, Juri G.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164664/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164664/

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