Cla4 kinase triggers destruction of the Rac1-GEF Cdc24 during polarized growth in Ustilago maydis
In the dimorphic fungus Ustilago maydis, Rac1 and its activator Cdc24 are essential for hyphal tip growth. Rac1 is shown to stimulate Cla4 kinase, which in turn triggers destruction of Cdc24. Expression of stabilized Cdc24 interferes with cell polarization, indicating that negative feedback regulati...
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164470/ |