Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma

Foxp3+ regulatory T lymphocytes (Tregs) usually act as an immune suppressor and correlate with poorer survival in malignancies. This study aims to investigate the distribution and characterization of Foxp3+ subset in peripheral blood mononuclear cells (PBMCs) and tumor tissues from extranodal NK/T c...

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Main Authors:	Peng, Rou-Jun, Huang, Zhou-Feng, Zhang, Yi-Lan, Yuan, Zhong-Yu, Xia, Yi, Jiang, Wen-Qi, Zeng, Yi-Xin, Li, Jiang
Format:	Online
Language:	English
Published:	Ivyspring International Publisher 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164152/

id	pubmed-3164152
recordtype	oai_dc
spelling	pubmed-31641522011-09-12 Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma Peng, Rou-Jun Huang, Zhou-Feng Zhang, Yi-Lan Yuan, Zhong-Yu Xia, Yi Jiang, Wen-Qi Zeng, Yi-Xin Li, Jiang Research Paper Foxp3+ regulatory T lymphocytes (Tregs) usually act as an immune suppressor and correlate with poorer survival in malignancies. This study aims to investigate the distribution and characterization of Foxp3+ subset in peripheral blood mononuclear cells (PBMCs) and tumor tissues from extranodal NK/T cell lymphoma (ENKTL). Our study showed the percentage of Foxp3+ subset from PBMC was significantly higher than that of healthy individuals (P<0.001). The Foxp3+ subset from PBMCs expressed CD45RO, CTLA4, GITR, CCR7, and had an IL-10highIFNγ+TGFβ+IL-2lowIL-17low cytokine secreting phenotype. Interestingly, the existence of EBV antigen-specific CD8+Foxp3+ Tregs was discovered in ENKTL. Furthermore, the high density of Foxp3+ TILs was associated with improved progression-free survival (PFS) in ENKTL patients (P<0.05). Collectively, our study implicates that EBV antigens could induce antigen-specific CD8+Foxp3+ Tregs in ENKTL, and Foxp3+ TILs is an independent factor for PFS in ENKTL. Ivyspring International Publisher 2011-08-19 /pmc/articles/PMC3164152/ /pubmed/21912510 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Peng, Rou-Jun Huang, Zhou-Feng Zhang, Yi-Lan Yuan, Zhong-Yu Xia, Yi Jiang, Wen-Qi Zeng, Yi-Xin Li, Jiang
spellingShingle	Peng, Rou-Jun Huang, Zhou-Feng Zhang, Yi-Lan Yuan, Zhong-Yu Xia, Yi Jiang, Wen-Qi Zeng, Yi-Xin Li, Jiang Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma
author_facet	Peng, Rou-Jun Huang, Zhou-Feng Zhang, Yi-Lan Yuan, Zhong-Yu Xia, Yi Jiang, Wen-Qi Zeng, Yi-Xin Li, Jiang
author_sort	Peng, Rou-Jun
title	Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma
title_short	Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma
title_full	Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma
title_fullStr	Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma
title_full_unstemmed	Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma
title_sort	circulating and tumor-infiltrating foxp3+ regulatory t cell subset in chinese patients with extranodal nk/t cell lymphoma
description	Foxp3+ regulatory T lymphocytes (Tregs) usually act as an immune suppressor and correlate with poorer survival in malignancies. This study aims to investigate the distribution and characterization of Foxp3+ subset in peripheral blood mononuclear cells (PBMCs) and tumor tissues from extranodal NK/T cell lymphoma (ENKTL). Our study showed the percentage of Foxp3+ subset from PBMC was significantly higher than that of healthy individuals (P<0.001). The Foxp3+ subset from PBMCs expressed CD45RO, CTLA4, GITR, CCR7, and had an IL-10highIFNγ+TGFβ+IL-2lowIL-17low cytokine secreting phenotype. Interestingly, the existence of EBV antigen-specific CD8+Foxp3+ Tregs was discovered in ENKTL. Furthermore, the high density of Foxp3+ TILs was associated with improved progression-free survival (PFS) in ENKTL patients (P<0.05). Collectively, our study implicates that EBV antigens could induce antigen-specific CD8+Foxp3+ Tregs in ENKTL, and Foxp3+ TILs is an independent factor for PFS in ENKTL.
publisher	Ivyspring International Publisher
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164152/
_version_	1611473205657075712

Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma

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