The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans

The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans

Aging is associated with increased central aortic systolic pressure (CSP) and pulse pressure which are predictive of cardiovascular events. Mechanisms implicated for higher central pressures include a higher forward incident pressure wave (P1), higher augmented pressure (AP), and shorter reflected w...

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Main Authors: Kamran, Haroon, Lazar, Jason M., Patel, Rinkesh, Maraj, IIir, Berman, Heather, Salciccioli, Louis
Format: Online
Language:English
Published: SAGE-Hindawi Access to Research 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163024/
id pubmed-3163024
recordtype oai_dc
spelling pubmed-31630242011-08-29 The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans Kamran, Haroon Lazar, Jason M. Patel, Rinkesh Maraj, IIir Berman, Heather Salciccioli, Louis Research Article Aging is associated with increased central aortic systolic pressure (CSP) and pulse pressure which are predictive of cardiovascular events. Mechanisms implicated for higher central pressures include a higher forward incident pressure wave (P1), higher augmented pressure (AP), and shorter reflected wave round trip travel time (Tr). African-Americans (AA) have more frequent and deleterious blood pressure elevation. Using applanation tonometry, we studied the association of age and CSP with P1 and AP in 900 AA subjects. Data showed that in subjects ≤50 years old, CSP was mediated by AP but not P1 or Tr, whereas in those >50, CSP was mediated by both AP and P1 and to a lesser extent by Tr. Predictive models were significant (R 2 = 0.97) for both age groups. In conclusion, wave reflection is the primary determinant of CSP in younger AA, while in older subjects, CSP is mediated by both the magnitude and timing of wave reflection as well as aortic impedance. SAGE-Hindawi Access to Research 2011 2011-08-24 /pmc/articles/PMC3163024/ /pubmed/21876787 http://dx.doi.org/10.4061/2011/585703 Text en Copyright © 2011 Haroon Kamran et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Kamran, Haroon
Lazar, Jason M.
Patel, Rinkesh
Maraj, IIir
Berman, Heather
Salciccioli, Louis
spellingShingle Kamran, Haroon
Lazar, Jason M.
Patel, Rinkesh
Maraj, IIir
Berman, Heather
Salciccioli, Louis
The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans
author_facet Kamran, Haroon
Lazar, Jason M.
Patel, Rinkesh
Maraj, IIir
Berman, Heather
Salciccioli, Louis
author_sort Kamran, Haroon
title The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans
title_short The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans
title_full The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans
title_fullStr The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans
title_full_unstemmed The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans
title_sort age-dependent contribution of aortic incident and reflected pressure waves to central blood pressure in african-americans
description Aging is associated with increased central aortic systolic pressure (CSP) and pulse pressure which are predictive of cardiovascular events. Mechanisms implicated for higher central pressures include a higher forward incident pressure wave (P1), higher augmented pressure (AP), and shorter reflected wave round trip travel time (Tr). African-Americans (AA) have more frequent and deleterious blood pressure elevation. Using applanation tonometry, we studied the association of age and CSP with P1 and AP in 900 AA subjects. Data showed that in subjects ≤50 years old, CSP was mediated by AP but not P1 or Tr, whereas in those >50, CSP was mediated by both AP and P1 and to a lesser extent by Tr. Predictive models were significant (R 2 = 0.97) for both age groups. In conclusion, wave reflection is the primary determinant of CSP in younger AA, while in older subjects, CSP is mediated by both the magnitude and timing of wave reflection as well as aortic impedance.
publisher SAGE-Hindawi Access to Research
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163024/
_version_ 1611472932075208704

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