The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. Examining checkpoint-dependent mechanisms controlling fork stability, we find that fork reversal and dormant origin firing due to checkpoint defects are rescued in checkpoint mutant...

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Bibliographic Details
Main Authors: Bermejo, Rodrigo, Capra, Thelma, Jossen, Rachel, Colosio, Arianna, Frattini, Camilla, Carotenuto, Walter, Cocito, Andrea, Doksani, Ylli, Klein, Hannah, Gómez-González, Belén, Aguilera, Andrés, Katou, Yuki, Shirahige, Katsuhiko, Foiani, Marco
Format: Online
Language:English
Published: Cell Press 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160733/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160733/

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