Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective

Malnutrition is common among older persons, with important consequences increasing frailty and morbidity and reducing health expectancy. On the contrary, calorie restriction (CR, a low-calorie dietary regimen with adequate nutrition) slows the progression of age-related diseases and extends the life...

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Main Authors:	Valerio, Alessandra, D'Antona, Giuseppe, Nisoli, Enzo
Format:	Online
Language:	English
Published:	Impact Journals LLC 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156598/

id	pubmed-3156598
recordtype	oai_dc
spelling	pubmed-31565982011-08-17 Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective Valerio, Alessandra D'Antona, Giuseppe Nisoli, Enzo Review Malnutrition is common among older persons, with important consequences increasing frailty and morbidity and reducing health expectancy. On the contrary, calorie restriction (CR, a low-calorie dietary regimen with adequate nutrition) slows the progression of age-related diseases and extends the lifespan of many species. Identification of strategies mimicking key CR mechanisms – increased mitochondrial respiration and reduced production of oxygen radicals – is a hot topic in gerontology. Dietary supplementation with essential and/or branched chain amino acids (BCAAs) exerts a variety of beneficial effects in experimental animals and humans and has been recently demonstrated to support cardiac and skeletal muscle mitochondrial biogenesis, prevent oxidative damage, and enhance physical endurance in middle-aged mice, resulting in prolonged survival. Here we review recent studies addressing the possible role of BCAAs in energy metabolism and in the longevity of species ranging from unicellular organisms to mammals. We also summarize observations from human studies supporting the exciting hypothesis that dietary BCAA enriched mixture supplementation might be a health-promoting strategy in aged patients at risk. Impact Journals LLC 2011-04-30 /pmc/articles/PMC3156598/ /pubmed/21566257 Text en Copyright: © 2011 Valerio et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Valerio, Alessandra D'Antona, Giuseppe Nisoli, Enzo
spellingShingle	Valerio, Alessandra D'Antona, Giuseppe Nisoli, Enzo Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
author_facet	Valerio, Alessandra D'Antona, Giuseppe Nisoli, Enzo
author_sort	Valerio, Alessandra
title	Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
title_short	Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
title_full	Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
title_fullStr	Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
title_full_unstemmed	Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
title_sort	branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
description	Malnutrition is common among older persons, with important consequences increasing frailty and morbidity and reducing health expectancy. On the contrary, calorie restriction (CR, a low-calorie dietary regimen with adequate nutrition) slows the progression of age-related diseases and extends the lifespan of many species. Identification of strategies mimicking key CR mechanisms – increased mitochondrial respiration and reduced production of oxygen radicals – is a hot topic in gerontology. Dietary supplementation with essential and/or branched chain amino acids (BCAAs) exerts a variety of beneficial effects in experimental animals and humans and has been recently demonstrated to support cardiac and skeletal muscle mitochondrial biogenesis, prevent oxidative damage, and enhance physical endurance in middle-aged mice, resulting in prolonged survival. Here we review recent studies addressing the possible role of BCAAs in energy metabolism and in the longevity of species ranging from unicellular organisms to mammals. We also summarize observations from human studies supporting the exciting hypothesis that dietary BCAA enriched mixture supplementation might be a health-promoting strategy in aged patients at risk.
publisher	Impact Journals LLC
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156598/
_version_	1611470988133793792

Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective

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