Reconstitution of the Costunolide Biosynthetic Pathway in Yeast and Nicotiana benthamiana

The sesquiterpene costunolide has a broad range of biological activities and is the parent compound for many other biologically active sesquiterpenes such as parthenolide. Two enzymes of the pathway leading to costunolide have been previously characterized: germacrene A synthase (GAS) and germacrene...

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Main Authors: Liu, Qing, Majdi, Mohammad, Cankar, Katarina, Goedbloed, Miriam, Charnikhova, Tatsiana, Verstappen, Francel W. A., de Vos, Ric C. H., Beekwilder, Jules, van der Krol, Sander, Bouwmeester, Harro J.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156125/