Estimates of the Proportion of Older White Men Who Would Be Recommended for Pharmacologic Treatment by the New US National Osteoporosis Foundation Guidelines

Estimates of the Proportion of Older White Men Who Would Be Recommended for Pharmacologic Treatment by the New US National Osteoporosis Foundation Guidelines

The new US National Osteoporosis Foundation's (NOF's) Clinician's Guide to Prevention and Treatment of Osteoporosis includes criteria for recommending pharmacologic treatment based on history of hip or vertebral fracture, femoral neck or spine bone mineral density (BMD) T-scores of −2...

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Main Authors: Donaldson, Meghan G, Cawthon, Peggy M, Lui, Lily Y, Schousboe, John T, Ensrud, Kristine E, Taylor, Brent C, Cauley, Jane A, Hillier, Teresa A, Dam, Thuy T, Curtis, Jeff R, Black, Dennis M, Bauer, Douglas C, Orwoll, Eric S, Cummings, Steven R
Format: Online
Language:English
Published: Wiley Subscription Services, Inc., A Wiley Company 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153995/
id pubmed-3153995
recordtype oai_dc
spelling pubmed-31539952011-08-19 Estimates of the Proportion of Older White Men Who Would Be Recommended for Pharmacologic Treatment by the New US National Osteoporosis Foundation Guidelines Donaldson, Meghan G Cawthon, Peggy M Lui, Lily Y Schousboe, John T Ensrud, Kristine E Taylor, Brent C Cauley, Jane A Hillier, Teresa A Dam, Thuy T Curtis, Jeff R Black, Dennis M Bauer, Douglas C Orwoll, Eric S Cummings, Steven R Original Article The new US National Osteoporosis Foundation's (NOF's) Clinician's Guide to Prevention and Treatment of Osteoporosis includes criteria for recommending pharmacologic treatment based on history of hip or vertebral fracture, femoral neck or spine bone mineral density (BMD) T-scores of −2.5 or less, and presence of low bone mass at the femoral neck or spine plus a 10-year risk of hip fracture of 3% or greater or of major osteoporotic fracture of 20% or greater. The proportion of men who would be recommended for treatment by these guidelines is not known. We applied the NOF criteria for treatment to men participating in the Osteoporotic Fractures in Men Study (MrOS). To determine how the MrOS population differs from the general US population of Caucasian men aged 65 years and older, we compared men in MrOS with men who participated in the National Health and Nutrition Examination Survey (NHANES) III on criteria included in the NOF treatment guidelines that were common to both cohorts. Compared with NHANES III, men in MrOS had higher femoral neck BMD values. Application of NOF guidelines to MrOS data estimated that at least 34% of US white men aged 65 years and older and 49% of those aged 75 years and older would be recommended for drug treatment. Application of the new NOF guidelines would result in recommending a very large proportion of white men in the United States for pharmacologic treatment of osteoporosis, for many of whom the efficacy of treatment is unknown. © 2010 American Society for Bone and Mineral Research. Wiley Subscription Services, Inc., A Wiley Company 2010-07 2010-02-04 /pmc/articles/PMC3153995/ /pubmed/20200971 http://dx.doi.org/10.1002/jbmr.55 Text en Copyright © 2010 American Society for Bone and Mineral Research http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Donaldson, Meghan G
Cawthon, Peggy M
Lui, Lily Y
Schousboe, John T
Ensrud, Kristine E
Taylor, Brent C
Cauley, Jane A
Hillier, Teresa A
Dam, Thuy T
Curtis, Jeff R
Black, Dennis M
Bauer, Douglas C
Orwoll, Eric S
Cummings, Steven R
spellingShingle Donaldson, Meghan G
Cawthon, Peggy M
Lui, Lily Y
Schousboe, John T
Ensrud, Kristine E
Taylor, Brent C
Cauley, Jane A
Hillier, Teresa A
Dam, Thuy T
Curtis, Jeff R
Black, Dennis M
Bauer, Douglas C
Orwoll, Eric S
Cummings, Steven R
Estimates of the Proportion of Older White Men Who Would Be Recommended for Pharmacologic Treatment by the New US National Osteoporosis Foundation Guidelines
author_facet Donaldson, Meghan G
Cawthon, Peggy M
Lui, Lily Y
Schousboe, John T
Ensrud, Kristine E
Taylor, Brent C
Cauley, Jane A
Hillier, Teresa A
Dam, Thuy T
Curtis, Jeff R
Black, Dennis M
Bauer, Douglas C
Orwoll, Eric S
Cummings, Steven R
author_sort Donaldson, Meghan G
title Estimates of the Proportion of Older White Men Who Would Be Recommended for Pharmacologic Treatment by the New US National Osteoporosis Foundation Guidelines
title_short Estimates of the Proportion of Older White Men Who Would Be Recommended for Pharmacologic Treatment by the New US National Osteoporosis Foundation Guidelines
title_full Estimates of the Proportion of Older White Men Who Would Be Recommended for Pharmacologic Treatment by the New US National Osteoporosis Foundation Guidelines
title_fullStr Estimates of the Proportion of Older White Men Who Would Be Recommended for Pharmacologic Treatment by the New US National Osteoporosis Foundation Guidelines
title_full_unstemmed Estimates of the Proportion of Older White Men Who Would Be Recommended for Pharmacologic Treatment by the New US National Osteoporosis Foundation Guidelines
title_sort estimates of the proportion of older white men who would be recommended for pharmacologic treatment by the new us national osteoporosis foundation guidelines
description The new US National Osteoporosis Foundation's (NOF's) Clinician's Guide to Prevention and Treatment of Osteoporosis includes criteria for recommending pharmacologic treatment based on history of hip or vertebral fracture, femoral neck or spine bone mineral density (BMD) T-scores of −2.5 or less, and presence of low bone mass at the femoral neck or spine plus a 10-year risk of hip fracture of 3% or greater or of major osteoporotic fracture of 20% or greater. The proportion of men who would be recommended for treatment by these guidelines is not known. We applied the NOF criteria for treatment to men participating in the Osteoporotic Fractures in Men Study (MrOS). To determine how the MrOS population differs from the general US population of Caucasian men aged 65 years and older, we compared men in MrOS with men who participated in the National Health and Nutrition Examination Survey (NHANES) III on criteria included in the NOF treatment guidelines that were common to both cohorts. Compared with NHANES III, men in MrOS had higher femoral neck BMD values. Application of NOF guidelines to MrOS data estimated that at least 34% of US white men aged 65 years and older and 49% of those aged 75 years and older would be recommended for drug treatment. Application of the new NOF guidelines would result in recommending a very large proportion of white men in the United States for pharmacologic treatment of osteoporosis, for many of whom the efficacy of treatment is unknown. © 2010 American Society for Bone and Mineral Research.
publisher Wiley Subscription Services, Inc., A Wiley Company
publishDate 2010
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153995/
_version_ 1611470332619653120

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