Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer

Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer

Traditional medicine and diet has served mankind through the ages for prevention and treatment of most chronic diseases. Mounting evidence suggests that chronic inflammation mediates most chronic diseases, including cancer. More than other transcription factors, nuclear factor-kappaB (NF-κB) and STA...

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Main Authors: Yadav, Vivek R., Prasad, Sahdeo, Sung, Bokyung, Kannappan, Ramaswamy, Aggarwal, Bharat B.
Format: Online
Language:English
Published: MDPI 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153165/
id pubmed-3153165
recordtype oai_dc
spelling pubmed-31531652011-11-08 Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer Yadav, Vivek R. Prasad, Sahdeo Sung, Bokyung Kannappan, Ramaswamy Aggarwal, Bharat B. Review Traditional medicine and diet has served mankind through the ages for prevention and treatment of most chronic diseases. Mounting evidence suggests that chronic inflammation mediates most chronic diseases, including cancer. More than other transcription factors, nuclear factor-kappaB (NF-κB) and STAT3 have emerged as major regulators of inflammation, cellular transformation, and tumor cell survival, proliferation, invasion, angiogenesis, and metastasis. Thus, agents that can inhibit NF-κB and STAT3 activation pathways have the potential to both prevent and treat cancer. In this review, we examine the potential of one group of compounds called triterpenes, derived from traditional medicine and diet for their ability to suppress inflammatory pathways linked to tumorigenesis. These triterpenes include avicins, betulinic acid, boswellic acid, celastrol, diosgenin, madecassic acid, maslinic acid, momordin, saikosaponins, platycodon, pristimerin, ursolic acid, and withanolide. This review thus supports the famous adage of Hippocrates, “Let food be thy medicine and medicine be thy food”. MDPI 2010-10-22 /pmc/articles/PMC3153165/ /pubmed/22069560 http://dx.doi.org/10.3390/toxins2102428 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Yadav, Vivek R.
Prasad, Sahdeo
Sung, Bokyung
Kannappan, Ramaswamy
Aggarwal, Bharat B.
spellingShingle Yadav, Vivek R.
Prasad, Sahdeo
Sung, Bokyung
Kannappan, Ramaswamy
Aggarwal, Bharat B.
Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer
author_facet Yadav, Vivek R.
Prasad, Sahdeo
Sung, Bokyung
Kannappan, Ramaswamy
Aggarwal, Bharat B.
author_sort Yadav, Vivek R.
title Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer
title_short Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer
title_full Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer
title_fullStr Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer
title_full_unstemmed Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer
title_sort targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer
description Traditional medicine and diet has served mankind through the ages for prevention and treatment of most chronic diseases. Mounting evidence suggests that chronic inflammation mediates most chronic diseases, including cancer. More than other transcription factors, nuclear factor-kappaB (NF-κB) and STAT3 have emerged as major regulators of inflammation, cellular transformation, and tumor cell survival, proliferation, invasion, angiogenesis, and metastasis. Thus, agents that can inhibit NF-κB and STAT3 activation pathways have the potential to both prevent and treat cancer. In this review, we examine the potential of one group of compounds called triterpenes, derived from traditional medicine and diet for their ability to suppress inflammatory pathways linked to tumorigenesis. These triterpenes include avicins, betulinic acid, boswellic acid, celastrol, diosgenin, madecassic acid, maslinic acid, momordin, saikosaponins, platycodon, pristimerin, ursolic acid, and withanolide. This review thus supports the famous adage of Hippocrates, “Let food be thy medicine and medicine be thy food”.
publisher MDPI
publishDate 2010
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153165/
_version_ 1611470020971331584

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