Small Regulatory RNA and Legionella pneumophila
Legionella pneumophila is a gram-negative bacterial species that is ubiquitous in almost any aqueous environment. It is the agent of Legionnaires’ disease, an acute and often under-reported form of pneumonia. In mammals, L. pneumophila replicates inside macrophages within a modified vacuole. Many pr...
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Frontiers Research Foundation
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153055/ |
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pubmed-31530552011-08-10 Small Regulatory RNA and Legionella pneumophila Faucher, Sébastien P. Shuman, Howard A. Microbiology Legionella pneumophila is a gram-negative bacterial species that is ubiquitous in almost any aqueous environment. It is the agent of Legionnaires’ disease, an acute and often under-reported form of pneumonia. In mammals, L. pneumophila replicates inside macrophages within a modified vacuole. Many protein regulators have been identified that control virulence-related properties, including RpoS, LetA/LetS, and PmrA/PmrB. In the past few years, the importance of regulation of virulence factors by small regulatory RNA (sRNAs) has been increasingly appreciated. This is also the case in L. pneumophila where three sRNAs (RsmY, RsmZ, and 6S RNA) were recently shown to be important determinants of virulence regulation and 79 actively transcribed sRNAs were identified. In this review we describe current knowledge about sRNAs and their regulatory properties and how this relates to the known regulatory systems of L. pneumophila. We also provide a model for sRNA-mediated control of gene expression that serves as a framework for understanding the regulation of virulence-related properties of L. pneumophila. Frontiers Research Foundation 2011-05-06 /pmc/articles/PMC3153055/ /pubmed/21833335 http://dx.doi.org/10.3389/fmicb.2011.00098 Text en Copyright © 2011 Faucher and Shuman. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Faucher, Sébastien P. Shuman, Howard A. |
| spellingShingle |
Faucher, Sébastien P. Shuman, Howard A. Small Regulatory RNA and Legionella pneumophila |
| author_facet |
Faucher, Sébastien P. Shuman, Howard A. |
| author_sort |
Faucher, Sébastien P. |
| title |
Small Regulatory RNA and Legionella pneumophila |
| title_short |
Small Regulatory RNA and Legionella pneumophila |
| title_full |
Small Regulatory RNA and Legionella pneumophila |
| title_fullStr |
Small Regulatory RNA and Legionella pneumophila |
| title_full_unstemmed |
Small Regulatory RNA and Legionella pneumophila |
| title_sort |
small regulatory rna and legionella pneumophila |
| description |
Legionella pneumophila is a gram-negative bacterial species that is ubiquitous in almost any aqueous environment. It is the agent of Legionnaires’ disease, an acute and often under-reported form of pneumonia. In mammals, L. pneumophila replicates inside macrophages within a modified vacuole. Many protein regulators have been identified that control virulence-related properties, including RpoS, LetA/LetS, and PmrA/PmrB. In the past few years, the importance of regulation of virulence factors by small regulatory RNA (sRNAs) has been increasingly appreciated. This is also the case in L. pneumophila where three sRNAs (RsmY, RsmZ, and 6S RNA) were recently shown to be important determinants of virulence regulation and 79 actively transcribed sRNAs were identified. In this review we describe current knowledge about sRNAs and their regulatory properties and how this relates to the known regulatory systems of L. pneumophila. We also provide a model for sRNA-mediated control of gene expression that serves as a framework for understanding the regulation of virulence-related properties of L. pneumophila. |
| publisher |
Frontiers Research Foundation |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153055/ |
| _version_ |
1611469988862885888 |