Genetic engineering of human ES and iPS cells using TALE nucleases

Genetic engineering of human ES and iPS cells using TALE nucleases

Targeted genetic engineering of human pluripotent cells is a prerequisite for exploiting their full potential. Such genetic manipulations can be achieved using site-specific nucleases. Here, we engineered Transcription Activation-Like Effector Nucleases (TALENs) for five distinct genomic loci. At al...

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Bibliographic Details
Main Authors: Hockemeyer, Dirk, Wang, Haoyi, Kiani, Samira, Lai, Christine S, Gao, Qing, Cassady, John P, Cost, Gregory J, Zhang, Lei, Santiago, Yolanda, Miller, Jeffrey C, Zeitler, Bryan, Cherone, Jennifer M, Meng, Xiangdong, Hinkley, Sarah J, Rebar, Edward J, Gregory, Philip D, Urnov, Fyodor D, Jaenisch, Rudolf
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152587/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152587/

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