Primary Graft Failure after Heart Transplantation

Primary graft failure (PGF) is a devastating complication that occurs in the immediate postoperative period following heart transplantation. It manifests as severe ventricular dysfunction of the donor graft and carries significant mortality and morbidity. In the last decade, advances in pharmacologi...

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Main Authors:	Iyer, Arjun, Kumarasinghe, Gayathri, Hicks, Mark, Watson, Alasdair, Gao, Ling, Doyle, Aoife, Keogh, Anne, Kotlyar, Eugene, Hayward, Christopher, Dhital, Kumud, Granger, Emily, Jansz, Paul, Pye, Roger, Spratt, Phillip, Macdonald, Peter Simon
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151502/

id	pubmed-3151502
recordtype	oai_dc
spelling	pubmed-31515022011-08-11 Primary Graft Failure after Heart Transplantation Iyer, Arjun Kumarasinghe, Gayathri Hicks, Mark Watson, Alasdair Gao, Ling Doyle, Aoife Keogh, Anne Kotlyar, Eugene Hayward, Christopher Dhital, Kumud Granger, Emily Jansz, Paul Pye, Roger Spratt, Phillip Macdonald, Peter Simon Review Article Primary graft failure (PGF) is a devastating complication that occurs in the immediate postoperative period following heart transplantation. It manifests as severe ventricular dysfunction of the donor graft and carries significant mortality and morbidity. In the last decade, advances in pharmacological treatment and mechanical circulatory support have improved the outlook for heart transplant recipients who develop this complication. Despite these advances in treatment, PGF is still the leading cause of death in the first 30 days after transplantation. In today's climate of significant organ shortages and growing waiting lists, transplant units worldwide have increasingly utilised “marginal donors” to try and bridge the gap between “supply and demand.” One of the costs of this strategy has been an increased incidence of PGF. As the threat of PGF increases, the challenges of predicting and preventing its occurrence, as well as the identification of more effective treatment modalities, are vital areas of active research and development. Hindawi Publishing Corporation 2011 2011-08-01 /pmc/articles/PMC3151502/ /pubmed/21837269 http://dx.doi.org/10.1155/2011/175768 Text en Copyright © 2011 Arjun Iyer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Iyer, Arjun Kumarasinghe, Gayathri Hicks, Mark Watson, Alasdair Gao, Ling Doyle, Aoife Keogh, Anne Kotlyar, Eugene Hayward, Christopher Dhital, Kumud Granger, Emily Jansz, Paul Pye, Roger Spratt, Phillip Macdonald, Peter Simon
spellingShingle	Iyer, Arjun Kumarasinghe, Gayathri Hicks, Mark Watson, Alasdair Gao, Ling Doyle, Aoife Keogh, Anne Kotlyar, Eugene Hayward, Christopher Dhital, Kumud Granger, Emily Jansz, Paul Pye, Roger Spratt, Phillip Macdonald, Peter Simon Primary Graft Failure after Heart Transplantation
author_facet	Iyer, Arjun Kumarasinghe, Gayathri Hicks, Mark Watson, Alasdair Gao, Ling Doyle, Aoife Keogh, Anne Kotlyar, Eugene Hayward, Christopher Dhital, Kumud Granger, Emily Jansz, Paul Pye, Roger Spratt, Phillip Macdonald, Peter Simon
author_sort	Iyer, Arjun
title	Primary Graft Failure after Heart Transplantation
title_short	Primary Graft Failure after Heart Transplantation
title_full	Primary Graft Failure after Heart Transplantation
title_fullStr	Primary Graft Failure after Heart Transplantation
title_full_unstemmed	Primary Graft Failure after Heart Transplantation
title_sort	primary graft failure after heart transplantation
description	Primary graft failure (PGF) is a devastating complication that occurs in the immediate postoperative period following heart transplantation. It manifests as severe ventricular dysfunction of the donor graft and carries significant mortality and morbidity. In the last decade, advances in pharmacological treatment and mechanical circulatory support have improved the outlook for heart transplant recipients who develop this complication. Despite these advances in treatment, PGF is still the leading cause of death in the first 30 days after transplantation. In today's climate of significant organ shortages and growing waiting lists, transplant units worldwide have increasingly utilised “marginal donors” to try and bridge the gap between “supply and demand.” One of the costs of this strategy has been an increased incidence of PGF. As the threat of PGF increases, the challenges of predicting and preventing its occurrence, as well as the identification of more effective treatment modalities, are vital areas of active research and development.
publisher	Hindawi Publishing Corporation
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151502/
_version_	1611469424271818752

Primary Graft Failure after Heart Transplantation

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