Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy

Occurrence of hypoglycemia in diabetes patients is very rare. We report here a case of frequent hypoglycemic attacks caused by inappropriate endogenous hyperinsulinemia in a female patient with poorly controlled diabetes and protein-losing gastroenteropathy. The blood glucose profiles of the patient...

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Main Authors:	Takahashi, Nobuhiko, Nagamine, Miho, Fukuda, Mitsuko, Motomura, Wataru, Abiko, Atsuko, Haneda, Masakazu, Fujiya, Mikihiro, Ieko, Masahiro, Kohgo, Yutaka
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150201/

id	pubmed-3150201
recordtype	oai_dc
spelling	pubmed-31502012011-08-08 Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy Takahashi, Nobuhiko Nagamine, Miho Fukuda, Mitsuko Motomura, Wataru Abiko, Atsuko Haneda, Masakazu Fujiya, Mikihiro Ieko, Masahiro Kohgo, Yutaka Case Report Occurrence of hypoglycemia in diabetes patients is very rare. We report here a case of frequent hypoglycemic attacks caused by inappropriate endogenous hyperinsulinemia in a female patient with poorly controlled diabetes and protein-losing gastroenteropathy. The blood glucose profiles of the patient were unstable. Results of the fasting test performed to investigate the cause of hypoglycemia suggested endogenous hyperinsulinism. Repeated selective arterial calcium injection tests suggested that hyperinsulinemia might be extrapancreatic in origin. However, efforts to detect a responsible lesion such as insulinoma were unsuccessful. Octreotide was used for the treatment of hypoglycemia and protein-losing gastroenteropathy. After treatment, although her leg edema caused by hypoalbuminemia persisted, hypoglycemia almost disappeared. Hindawi Publishing Corporation 2011 2011-08-04 /pmc/articles/PMC3150201/ /pubmed/21826148 http://dx.doi.org/10.1155/2011/381203 Text en Copyright © 2011 Nobuhiko Takahashi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Takahashi, Nobuhiko Nagamine, Miho Fukuda, Mitsuko Motomura, Wataru Abiko, Atsuko Haneda, Masakazu Fujiya, Mikihiro Ieko, Masahiro Kohgo, Yutaka
spellingShingle	Takahashi, Nobuhiko Nagamine, Miho Fukuda, Mitsuko Motomura, Wataru Abiko, Atsuko Haneda, Masakazu Fujiya, Mikihiro Ieko, Masahiro Kohgo, Yutaka Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy
author_facet	Takahashi, Nobuhiko Nagamine, Miho Fukuda, Mitsuko Motomura, Wataru Abiko, Atsuko Haneda, Masakazu Fujiya, Mikihiro Ieko, Masahiro Kohgo, Yutaka
author_sort	Takahashi, Nobuhiko
title	Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy
title_short	Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy
title_full	Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy
title_fullStr	Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy
title_full_unstemmed	Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy
title_sort	octreotide-treated diabetes accompanied by endogenous hyperinsulinemic hypoglycemia and protein-losing gastroenteropathy
description	Occurrence of hypoglycemia in diabetes patients is very rare. We report here a case of frequent hypoglycemic attacks caused by inappropriate endogenous hyperinsulinemia in a female patient with poorly controlled diabetes and protein-losing gastroenteropathy. The blood glucose profiles of the patient were unstable. Results of the fasting test performed to investigate the cause of hypoglycemia suggested endogenous hyperinsulinism. Repeated selective arterial calcium injection tests suggested that hyperinsulinemia might be extrapancreatic in origin. However, efforts to detect a responsible lesion such as insulinoma were unsuccessful. Octreotide was used for the treatment of hypoglycemia and protein-losing gastroenteropathy. After treatment, although her leg edema caused by hypoalbuminemia persisted, hypoglycemia almost disappeared.
publisher	Hindawi Publishing Corporation
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150201/
_version_	1611469128375205888

Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy

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