Urine Antibiotic Activity in Patients Presenting to Hospitals in Laos: Implications for Worsening Antibiotic Resistance
Widespread use of antibiotics may be important in the spread of antimicrobial resistance. We estimated the proportion of Lao in- and outpatients who had taken antibiotics before medical consultation by detecting antibiotic activity in their urine added to lawns of Bacillus stearothermophilus, Escher...
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The American Society of Tropical Medicine and Hygiene
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144829/ |
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pubmed-31448292011-08-09 Urine Antibiotic Activity in Patients Presenting to Hospitals in Laos: Implications for Worsening Antibiotic Resistance Khennavong, Manisone Davone, Viengmon Vongsouvath, Manivanh Phetsouvanh, Rattanaphone Silisouk, Joy Rattana, Olay Mayxay, Mayfong Castonguay-Vanier, Josée Moore, Catrin E. Strobel, Michel Newton, Paul N. Articles Widespread use of antibiotics may be important in the spread of antimicrobial resistance. We estimated the proportion of Lao in- and outpatients who had taken antibiotics before medical consultation by detecting antibiotic activity in their urine added to lawns of Bacillus stearothermophilus, Escherichia coli, and Streptococcus pyogenes. In the retrospective (N = 2,058) and prospective studies (N = 1,153), 49.7% (95% confidence interval [CI] = 47.4–52.0) and 36.2% (95% CI = 33.4–38.9), respectively, of Vientiane patients had urinary antibiotic activity detected. The highest frequency of estimated antibiotic pre-treatment was found in patients recruited with suspected central nervous system infections and community-acquired septicemia (both 56.8%). In Vientiane, children had a higher frequency of estimated antibiotic pre-treatment than adults (60.0% versus 46.5%; P < 0.001). Antibiotic use based on patients histories was significantly less frequent than when estimated from urinary antibiotic activity (P < 0.0001). The American Society of Tropical Medicine and Hygiene 2011-08-01 /pmc/articles/PMC3144829/ /pubmed/21813851 http://dx.doi.org/10.4269/ajtmh.2011.11-0076 Text en ©The American Society of Tropical Medicine and Hygiene http://creativecommons.org/licenses/by/2.5/ This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Khennavong, Manisone Davone, Viengmon Vongsouvath, Manivanh Phetsouvanh, Rattanaphone Silisouk, Joy Rattana, Olay Mayxay, Mayfong Castonguay-Vanier, Josée Moore, Catrin E. Strobel, Michel Newton, Paul N. |
| spellingShingle |
Khennavong, Manisone Davone, Viengmon Vongsouvath, Manivanh Phetsouvanh, Rattanaphone Silisouk, Joy Rattana, Olay Mayxay, Mayfong Castonguay-Vanier, Josée Moore, Catrin E. Strobel, Michel Newton, Paul N. Urine Antibiotic Activity in Patients Presenting to Hospitals in Laos: Implications for Worsening Antibiotic Resistance |
| author_facet |
Khennavong, Manisone Davone, Viengmon Vongsouvath, Manivanh Phetsouvanh, Rattanaphone Silisouk, Joy Rattana, Olay Mayxay, Mayfong Castonguay-Vanier, Josée Moore, Catrin E. Strobel, Michel Newton, Paul N. |
| author_sort |
Khennavong, Manisone |
| title |
Urine Antibiotic Activity in Patients Presenting to Hospitals in Laos: Implications for Worsening Antibiotic Resistance |
| title_short |
Urine Antibiotic Activity in Patients Presenting to Hospitals in Laos: Implications for Worsening Antibiotic Resistance |
| title_full |
Urine Antibiotic Activity in Patients Presenting to Hospitals in Laos: Implications for Worsening Antibiotic Resistance |
| title_fullStr |
Urine Antibiotic Activity in Patients Presenting to Hospitals in Laos: Implications for Worsening Antibiotic Resistance |
| title_full_unstemmed |
Urine Antibiotic Activity in Patients Presenting to Hospitals in Laos: Implications for Worsening Antibiotic Resistance |
| title_sort |
urine antibiotic activity in patients presenting to hospitals in laos: implications for worsening antibiotic resistance |
| description |
Widespread use of antibiotics may be important in the spread of antimicrobial resistance. We estimated the proportion of Lao in- and outpatients who had taken antibiotics before medical consultation by detecting antibiotic activity in their urine added to lawns of Bacillus stearothermophilus, Escherichia coli, and Streptococcus pyogenes. In the retrospective (N = 2,058) and prospective studies (N = 1,153), 49.7% (95% confidence interval [CI] = 47.4–52.0) and 36.2% (95% CI = 33.4–38.9), respectively, of Vientiane patients had urinary antibiotic activity detected. The highest frequency of estimated antibiotic pre-treatment was found in patients recruited with suspected central nervous system infections and community-acquired septicemia (both 56.8%). In Vientiane, children had a higher frequency of estimated antibiotic pre-treatment than adults (60.0% versus 46.5%; P < 0.001). Antibiotic use based on patients histories was significantly less frequent than when estimated from urinary antibiotic activity (P < 0.0001). |
| publisher |
The American Society of Tropical Medicine and Hygiene |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144829/ |
| _version_ |
1611467889898946560 |