Regenerative capacity in newts is not altered by repeated regeneration and ageing

The extent to which adult newts retain regenerative capability remains one of the greatest unanswered questions in the regeneration field. Here we report a long-term lens regeneration project spanning 16 years that was undertaken to address this question. Over that time, the lens was removed 18 time...

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Main Authors:	Eguchi, Goro, Eguchi, Yukiko, Nakamura, Kenta, Yadav, Manisha C., Millán, José Luis, Tsonis, Panagiotis A.
Format:	Online
Language:	English
Published:	Nature Publishing Group 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144589/

id	pubmed-3144589
recordtype	oai_dc
spelling	pubmed-31445892011-08-17 Regenerative capacity in newts is not altered by repeated regeneration and ageing Eguchi, Goro Eguchi, Yukiko Nakamura, Kenta Yadav, Manisha C. Millán, José Luis Tsonis, Panagiotis A. Article The extent to which adult newts retain regenerative capability remains one of the greatest unanswered questions in the regeneration field. Here we report a long-term lens regeneration project spanning 16 years that was undertaken to address this question. Over that time, the lens was removed 18 times from the same animals, and by the time of the last tissue collection, specimens were at least 30 years old. Regenerated lens tissues number 18 and number 17, from the last and the second to the last extraction, respectively, were analysed structurally and in terms of gene expression. Both exhibited structural properties identical to lenses from younger animals that had never experienced lens regeneration. Expression of mRNAs encoding key lens structural proteins or transcription factors was very similar to that of controls. Thus, contrary to the belief that regeneration becomes less efficient with time or repetition, repeated regeneration, even at old age, does not alter newt regenerative capacity. Nature Publishing Group 2011-07 2011-07-12 /pmc/articles/PMC3144589/ /pubmed/21750538 http://dx.doi.org/10.1038/ncomms1389 Text en Copyright © 2011, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Eguchi, Goro Eguchi, Yukiko Nakamura, Kenta Yadav, Manisha C. Millán, José Luis Tsonis, Panagiotis A.
spellingShingle	Eguchi, Goro Eguchi, Yukiko Nakamura, Kenta Yadav, Manisha C. Millán, José Luis Tsonis, Panagiotis A. Regenerative capacity in newts is not altered by repeated regeneration and ageing
author_facet	Eguchi, Goro Eguchi, Yukiko Nakamura, Kenta Yadav, Manisha C. Millán, José Luis Tsonis, Panagiotis A.
author_sort	Eguchi, Goro
title	Regenerative capacity in newts is not altered by repeated regeneration and ageing
title_short	Regenerative capacity in newts is not altered by repeated regeneration and ageing
title_full	Regenerative capacity in newts is not altered by repeated regeneration and ageing
title_fullStr	Regenerative capacity in newts is not altered by repeated regeneration and ageing
title_full_unstemmed	Regenerative capacity in newts is not altered by repeated regeneration and ageing
title_sort	regenerative capacity in newts is not altered by repeated regeneration and ageing
description	The extent to which adult newts retain regenerative capability remains one of the greatest unanswered questions in the regeneration field. Here we report a long-term lens regeneration project spanning 16 years that was undertaken to address this question. Over that time, the lens was removed 18 times from the same animals, and by the time of the last tissue collection, specimens were at least 30 years old. Regenerated lens tissues number 18 and number 17, from the last and the second to the last extraction, respectively, were analysed structurally and in terms of gene expression. Both exhibited structural properties identical to lenses from younger animals that had never experienced lens regeneration. Expression of mRNAs encoding key lens structural proteins or transcription factors was very similar to that of controls. Thus, contrary to the belief that regeneration becomes less efficient with time or repetition, repeated regeneration, even at old age, does not alter newt regenerative capacity.
publisher	Nature Publishing Group
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144589/
_version_	1611467809241432064

Regenerative capacity in newts is not altered by repeated regeneration and ageing

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