Structure-Activity relationship in mutated pyrazinamidases from Mycobacterium tuberculosis
The pncA gene codes the pyrazinamidase of Mycobacterium tuberculosis, which converts pyrazinamide to ammonia and pyrazinoic-acid, the active antituberculous compound. Pyrazinamidase mutations are associated to pyrazinamide-resistant phenotype, however how mutations affect the structure of the pyrazi...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Biomedical Informatics
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143395/ |