Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?
The c-AMP-responsive element binding protein (CREB) and its phosphorylated product (P-CREB) are nuclear proteins expressed after stimulation of pain-producing areas of the spinal cord. There is evidence indicating that central sensitization within dorsal horn neurons is dependent on P-CREB transcrip...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Springer Milan
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139063/ |