Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction

Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-bas...

Full description

Bibliographic Details
Main Authors:	Puranik, Amrutesh S., Halade, Ganesh, Kumar, Sandeep, Mogre, Ranjan, Apte, Kishori, Vaidya, Ashok D. B., Patwardhan, Bhushan
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137796/

id	pubmed-3137796
recordtype	oai_dc
spelling	pubmed-31377962011-07-22 Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction Puranik, Amrutesh S. Halade, Ganesh Kumar, Sandeep Mogre, Ranjan Apte, Kishori Vaidya, Ashok D. B. Patwardhan, Bhushan Original Article Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts. Hindawi Publishing Corporation 2011 2011-05-03 /pmc/articles/PMC3137796/ /pubmed/21785642 http://dx.doi.org/10.1093/ecam/nep237 Text en Copyright © 2011 Amrutesh S. Puranik et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Puranik, Amrutesh S. Halade, Ganesh Kumar, Sandeep Mogre, Ranjan Apte, Kishori Vaidya, Ashok D. B. Patwardhan, Bhushan
spellingShingle	Puranik, Amrutesh S. Halade, Ganesh Kumar, Sandeep Mogre, Ranjan Apte, Kishori Vaidya, Ashok D. B. Patwardhan, Bhushan Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction
author_facet	Puranik, Amrutesh S. Halade, Ganesh Kumar, Sandeep Mogre, Ranjan Apte, Kishori Vaidya, Ashok D. B. Patwardhan, Bhushan
author_sort	Puranik, Amrutesh S.
title	Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction
title_short	Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction
title_full	Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction
title_fullStr	Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction
title_full_unstemmed	Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction
title_sort	cassia auriculata: aspects of safety pharmacology and drug interaction
description	Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts.
publisher	Hindawi Publishing Corporation
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137796/
_version_	1611465877084962816

Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction

Similar Items