Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis

There is a growing evidence that serotoninergic systems modulate dopaminergic neurotransmission. We analyzed the association between the variations in the brain tryptophan hydroxylase 2 (TPH2) gene, a rate limiting enzyme for serotonin biosynthesis, and methamphetamine (METH) dependence/psychosis in...

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Main Authors:	Kobayashi, Hideaki, Ujike, Hiroshi, Iwata, Nakao, Inada, Toshiya, Yamada, Mitsuhiko, Sekine, Yoshimoto, Uchimura, Naohisa, Iyo, Masaomi, Ozaki, Norio, Itokawa, Masanari, Sora, Ichiro
Format:	Online
Language:	English
Published:	Bentham Science Publishers Ltd 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137177/

id	pubmed-3137177
recordtype	oai_dc
spelling	pubmed-31371772011-09-01 Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis Kobayashi, Hideaki Ujike, Hiroshi Iwata, Nakao Inada, Toshiya Yamada, Mitsuhiko Sekine, Yoshimoto Uchimura, Naohisa Iyo, Masaomi Ozaki, Norio Itokawa, Masanari Sora, Ichiro Article There is a growing evidence that serotoninergic systems modulate dopaminergic neurotransmission. We analyzed the association between the variations in the brain tryptophan hydroxylase 2 (TPH2) gene, a rate limiting enzyme for serotonin biosynthesis, and methamphetamine (METH) dependence/psychosis in a Japanese population. We found ten single nucleotide polymorphisms (SNPs) and two polynucleotide polymorphisms in TPH2 gene exons and exon-intron boundaries. A total of 162 patients and 243 controls were used for the association analysis between these polymorphisms and METH dependence/psychosis. No significant differences were observed in either genotypic or allelic frequencies between METH dependent/psychotic patients and controls. A global test of differentiation among samples based on haplotype frequencies showed no significant association. With respect to latency of psychosis, prognosis of psychosis, and spontaneous relapse, we found no significant association with these SNPs. These results suggest that the TPH2 gene variants may not be a factor in vulnerability to METH dependence/psychosis. Bentham Science Publishers Ltd 2011-03 /pmc/articles/PMC3137177/ /pubmed/21886586 http://dx.doi.org/10.2174/157015911795017335 Text en ©2011 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kobayashi, Hideaki Ujike, Hiroshi Iwata, Nakao Inada, Toshiya Yamada, Mitsuhiko Sekine, Yoshimoto Uchimura, Naohisa Iyo, Masaomi Ozaki, Norio Itokawa, Masanari Sora, Ichiro
spellingShingle	Kobayashi, Hideaki Ujike, Hiroshi Iwata, Nakao Inada, Toshiya Yamada, Mitsuhiko Sekine, Yoshimoto Uchimura, Naohisa Iyo, Masaomi Ozaki, Norio Itokawa, Masanari Sora, Ichiro Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis
author_facet	Kobayashi, Hideaki Ujike, Hiroshi Iwata, Nakao Inada, Toshiya Yamada, Mitsuhiko Sekine, Yoshimoto Uchimura, Naohisa Iyo, Masaomi Ozaki, Norio Itokawa, Masanari Sora, Ichiro
author_sort	Kobayashi, Hideaki
title	Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis
title_short	Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis
title_full	Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis
title_fullStr	Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis
title_full_unstemmed	Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis
title_sort	association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis
description	There is a growing evidence that serotoninergic systems modulate dopaminergic neurotransmission. We analyzed the association between the variations in the brain tryptophan hydroxylase 2 (TPH2) gene, a rate limiting enzyme for serotonin biosynthesis, and methamphetamine (METH) dependence/psychosis in a Japanese population. We found ten single nucleotide polymorphisms (SNPs) and two polynucleotide polymorphisms in TPH2 gene exons and exon-intron boundaries. A total of 162 patients and 243 controls were used for the association analysis between these polymorphisms and METH dependence/psychosis. No significant differences were observed in either genotypic or allelic frequencies between METH dependent/psychotic patients and controls. A global test of differentiation among samples based on haplotype frequencies showed no significant association. With respect to latency of psychosis, prognosis of psychosis, and spontaneous relapse, we found no significant association with these SNPs. These results suggest that the TPH2 gene variants may not be a factor in vulnerability to METH dependence/psychosis.
publisher	Bentham Science Publishers Ltd
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137177/
_version_	1611465726862819328

Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis

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