Genomic Analysis of Hepatitis B Virus Reveals Antigen State and Genotype as Sources of Evolutionary Rate Variation
Hepatitis B virus (HBV) genomes are small, semi-double-stranded DNA circular genomes that contain alternating overlapping reading frames and replicate through an RNA intermediary phase. This complex biology has presented a challenge to estimating an evolutionary rate for HBV, leading to difficulties...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Online |
Language: | English |
Published: |
Molecular Diversity Preservation International (MDPI)
2011
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136878/ |