Cross-Talk between Apolipoprotein E and Cytokines
Apolipoprotein E (apoE) is a multifunctional glycosylated protein characterized by its wide tissue distribution. Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease...
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Hindawi Publishing Corporation
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136159/ |
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pubmed-31361592011-07-19 Cross-Talk between Apolipoprotein E and Cytokines Zhang, Hongliang Wu, Li-Min Wu, Jiang Review Article Apolipoprotein E (apoE) is a multifunctional glycosylated protein characterized by its wide tissue distribution. Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorders such as multiple sclerosis and psoriasis. Among others, the role of apoE in modulating inflammation and oxidation is crucial in elucidating the risk factors of the above diseases since the function of apoE is closely linked with both proinflammatory and antiinflammatory cytokines. Moreover, apoE modulates inflammatory and immune responses in an isoform-dependent manner. Correspondingly, inflammatory cytokines can either upregulate or downregulate the production of apoE in various tissue types. However, studies on the interactions between apoE and cytokines occasionally yield conflicting results, highlighting the complex roles of apoE and cytokines in various disorders. The present paper summarizes the current knowledge about the cross-talk between apoE and cytokines, with emphasis on the effects of apoE on the Th1/Th2 balance. Hindawi Publishing Corporation 2011 2011-06-28 /pmc/articles/PMC3136159/ /pubmed/21772670 http://dx.doi.org/10.1155/2011/949072 Text en Copyright © 2011 Hongliang Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zhang, Hongliang Wu, Li-Min Wu, Jiang |
| spellingShingle |
Zhang, Hongliang Wu, Li-Min Wu, Jiang Cross-Talk between Apolipoprotein E and Cytokines |
| author_facet |
Zhang, Hongliang Wu, Li-Min Wu, Jiang |
| author_sort |
Zhang, Hongliang |
| title |
Cross-Talk between Apolipoprotein E and Cytokines |
| title_short |
Cross-Talk between Apolipoprotein E and Cytokines |
| title_full |
Cross-Talk between Apolipoprotein E and Cytokines |
| title_fullStr |
Cross-Talk between Apolipoprotein E and Cytokines |
| title_full_unstemmed |
Cross-Talk between Apolipoprotein E and Cytokines |
| title_sort |
cross-talk between apolipoprotein e and cytokines |
| description |
Apolipoprotein E (apoE) is a multifunctional glycosylated protein characterized by its wide tissue distribution. Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorders such as multiple sclerosis and psoriasis. Among others, the role of apoE in modulating inflammation and oxidation is crucial in elucidating the risk factors of the above diseases since the function of apoE is closely linked with both proinflammatory and antiinflammatory cytokines. Moreover, apoE modulates inflammatory and immune responses in an isoform-dependent manner. Correspondingly, inflammatory cytokines can either upregulate or downregulate the production of apoE in various tissue types. However, studies on the interactions between apoE and cytokines occasionally yield conflicting results, highlighting the complex roles of apoE and cytokines in various disorders. The present paper summarizes the current knowledge about the cross-talk between apoE and cytokines, with emphasis on the effects of apoE on the Th1/Th2 balance. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136159/ |
| _version_ |
1611465487475015680 |