Interactions between Glucocorticoid Treatment and Cis-Regulatory Polymorphisms Contribute to Cellular Response Phenotypes

Glucocorticoids (GCs) mediate physiological responses to environmental stress and are commonly used as pharmaceuticals. GCs act primarily through the GC receptor (GR, a transcription factor). Despite their clear biomedical importance, little is known about the genetic architecture of variation in GC...

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Bibliographic Details
Main Authors: Maranville, Joseph C., Luca, Francesca, Richards, Allison L., Wen, Xiaoquan, Witonsky, David B., Baxter, Shaneen, Stephens, Matthew, Di Rienzo, Anna
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131293/