Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) Infection

The inhibitory receptor programmed death-1 (PD-1) has the capacity to maintain peripheral tolerance and limit immunopathological damage; however, its precise role in fulminant viral hepatitis (FH) has yet to be described. Here, we investigated the functional mechanisms of PD-1 as related to FH patho...

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Bibliographic Details
Main Authors: Chen, Yongwen, Wu, Shengxi, Guo, Guoning, Fei, Lei, Guo, Sheng, Yang, Chengying, Fu, Xiaolan, Wu, Yuzhang
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131267/