Strategies in the Surgical Management of Atrial Fibrillation

Strategies in the Surgical Management of Atrial Fibrillation

Atrial fibrillation (AF) is associated with substantial morbidity, mortality, and economic burden and confers a lifetime risk of up to 25%. Current medical management involves thromboembolism prevention, rate, and rhythm control. An increased understanding of AF pathophysiology has led to enhanced p...

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Main Authors: Harling, Leanne, Athanasiou, Thanos, Ashrafian, Hutan, Nowell, Justin, Kourliouros, Antonios
Format: Online
Language:English
Published: SAGE-Hindawi Access to Research 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130973/
id pubmed-3130973
recordtype oai_dc
spelling pubmed-31309732011-07-11 Strategies in the Surgical Management of Atrial Fibrillation Harling, Leanne Athanasiou, Thanos Ashrafian, Hutan Nowell, Justin Kourliouros, Antonios Review Article Atrial fibrillation (AF) is associated with substantial morbidity, mortality, and economic burden and confers a lifetime risk of up to 25%. Current medical management involves thromboembolism prevention, rate, and rhythm control. An increased understanding of AF pathophysiology has led to enhanced pharmacological and medical therapies; however this is often limited by toxicity, variable symptom control, and inability to modulate the atrial substrate. Surgical AF ablation has been available since the original description of the Cox Maze procedure, either as a standalone or concomitant intervention. Advances in novel energy delivery systems have allowed the development of less technically demanding procedures potentially eliminating the need for median sternotomy and cardiopulmonary bypass. Variations in the definition, duration, and reporting of AF have produced methodological limitations impacting on the validity of interstudy comparisons. Standardization of these parameters may, in future, allow us to further evaluate clinical endpoints and establish the efficacy of these techniques. SAGE-Hindawi Access to Research 2011-06-12 /pmc/articles/PMC3130973/ /pubmed/21747988 http://dx.doi.org/10.4061/2011/439312 Text en Copyright © 2011 Leanne Harling et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Harling, Leanne
Athanasiou, Thanos
Ashrafian, Hutan
Nowell, Justin
Kourliouros, Antonios
spellingShingle Harling, Leanne
Athanasiou, Thanos
Ashrafian, Hutan
Nowell, Justin
Kourliouros, Antonios
Strategies in the Surgical Management of Atrial Fibrillation
author_facet Harling, Leanne
Athanasiou, Thanos
Ashrafian, Hutan
Nowell, Justin
Kourliouros, Antonios
author_sort Harling, Leanne
title Strategies in the Surgical Management of Atrial Fibrillation
title_short Strategies in the Surgical Management of Atrial Fibrillation
title_full Strategies in the Surgical Management of Atrial Fibrillation
title_fullStr Strategies in the Surgical Management of Atrial Fibrillation
title_full_unstemmed Strategies in the Surgical Management of Atrial Fibrillation
title_sort strategies in the surgical management of atrial fibrillation
description Atrial fibrillation (AF) is associated with substantial morbidity, mortality, and economic burden and confers a lifetime risk of up to 25%. Current medical management involves thromboembolism prevention, rate, and rhythm control. An increased understanding of AF pathophysiology has led to enhanced pharmacological and medical therapies; however this is often limited by toxicity, variable symptom control, and inability to modulate the atrial substrate. Surgical AF ablation has been available since the original description of the Cox Maze procedure, either as a standalone or concomitant intervention. Advances in novel energy delivery systems have allowed the development of less technically demanding procedures potentially eliminating the need for median sternotomy and cardiopulmonary bypass. Variations in the definition, duration, and reporting of AF have produced methodological limitations impacting on the validity of interstudy comparisons. Standardization of these parameters may, in future, allow us to further evaluate clinical endpoints and establish the efficacy of these techniques.
publisher SAGE-Hindawi Access to Research
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130973/
_version_ 1611464100702846976

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