Genome-Wide Local Ancestry Approach Identifies Genes and Variants Associated with Chemotherapeutic Susceptibility in African Americans

Chemotherapeutic agents are used in the treatment of many cancers, yet variable resistance and toxicities among individuals limit successful outcomes. Several studies have indicated outcome differences associated with ancestry among patients with various cancer types. Using both traditional SNP-base...

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Bibliographic Details
Main Authors: Wheeler, Heather E., Gorsic, Lidija K., Welsh, Marleen, Stark, Amy L., Gamazon, Eric R., Cox, Nancy J., Dolan, M. Eileen
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130766/