Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse

Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse

Adaptive evolution is characterized by positive and parallel, or repeated selection of mutations. Mouse adaptation of influenza A virus (IAV) produces virulent mutants that demonstrate positive and parallel evolution of mutations in the hemagglutinin (HA) receptor and non-structural protein 1 (NS1)...

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Main Authors: Ping, Jihui, Keleta, Liya, Forbes, Nicole E., Dankar, Samar, Stecho, William, Tyler, Shaun, Zhou, Yan, Babiuk, Lorne, Weingartl, Hana, Halpin, Rebecca A., Boyne, Alex, Bera, Jayati, Hostetler, Jessicah, Fedorova, Nadia B., Proudfoot, Katie, Katzel, Dan A., Stockwell, Tim B., Ghedin, Elodie, Spiro, David J., Brown, Earl G.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128085/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128085/

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