PredUs: a web server for predicting protein interfaces using structural neighbors

PredUs: a web server for predicting protein interfaces using structural neighbors

We describe PredUs, an interactive web server for the prediction of protein–protein interfaces. Potential interfacial residues for a query protein are identified by ‘mapping’ contacts from known interfaces of the query protein’s structural neighbors to surface residues of the query. We calculate a s...

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Main Authors: Zhang, Qiangfeng Cliff, Deng, Lei, Fisher, Markus, Guan, Jihong, Honig, Barry, Petrey, Donald
Format: Online
Language:English
Published: Oxford University Press 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125747/
id pubmed-3125747
recordtype oai_dc
spelling pubmed-31257472011-07-05 PredUs: a web server for predicting protein interfaces using structural neighbors Zhang, Qiangfeng Cliff Deng, Lei Fisher, Markus Guan, Jihong Honig, Barry Petrey, Donald Articles We describe PredUs, an interactive web server for the prediction of protein–protein interfaces. Potential interfacial residues for a query protein are identified by ‘mapping’ contacts from known interfaces of the query protein’s structural neighbors to surface residues of the query. We calculate a score for each residue to be interfacial with a support vector machine. Results can be visualized in a molecular viewer and a number of interactive features allow users to tailor a prediction to a particular hypothesis. The PredUs server is available at: http://wiki.c2b2.columbia.edu/honiglab_public/index.php/Software:PredUs. Oxford University Press 2011-07-01 2011-05-23 /pmc/articles/PMC3125747/ /pubmed/21609948 http://dx.doi.org/10.1093/nar/gkr311 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Zhang, Qiangfeng Cliff
Deng, Lei
Fisher, Markus
Guan, Jihong
Honig, Barry
Petrey, Donald
spellingShingle Zhang, Qiangfeng Cliff
Deng, Lei
Fisher, Markus
Guan, Jihong
Honig, Barry
Petrey, Donald
PredUs: a web server for predicting protein interfaces using structural neighbors
author_facet Zhang, Qiangfeng Cliff
Deng, Lei
Fisher, Markus
Guan, Jihong
Honig, Barry
Petrey, Donald
author_sort Zhang, Qiangfeng Cliff
title PredUs: a web server for predicting protein interfaces using structural neighbors
title_short PredUs: a web server for predicting protein interfaces using structural neighbors
title_full PredUs: a web server for predicting protein interfaces using structural neighbors
title_fullStr PredUs: a web server for predicting protein interfaces using structural neighbors
title_full_unstemmed PredUs: a web server for predicting protein interfaces using structural neighbors
title_sort predus: a web server for predicting protein interfaces using structural neighbors
description We describe PredUs, an interactive web server for the prediction of protein–protein interfaces. Potential interfacial residues for a query protein are identified by ‘mapping’ contacts from known interfaces of the query protein’s structural neighbors to surface residues of the query. We calculate a score for each residue to be interfacial with a support vector machine. Results can be visualized in a molecular viewer and a number of interactive features allow users to tailor a prediction to a particular hypothesis. The PredUs server is available at: http://wiki.c2b2.columbia.edu/honiglab_public/index.php/Software:PredUs.
publisher Oxford University Press
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125747/
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