Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1

Ionotropic glutamate receptors principally mediate fast excitatory transmission in the brain. Among the three classes of ionotropic glutamate receptors, kainate receptors (KARs) display a categorical brain distribution, which has been historically defined by 3H-radiolabeled kainate binding. Compared...

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Main Authors:	Straub, Christoph, Hunt, David L., Yamasaki, Miwako, Kim, Kwang S., Watanabe, Masahiko, Castillo, Pablo E., Tomita, Susumu
Format:	Online
Language:	English
Published:	2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125417/

id	pubmed-3125417
recordtype	oai_dc
spelling	pubmed-31254172012-01-01 Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1 Straub, Christoph Hunt, David L. Yamasaki, Miwako Kim, Kwang S. Watanabe, Masahiko Castillo, Pablo E. Tomita, Susumu Article Ionotropic glutamate receptors principally mediate fast excitatory transmission in the brain. Among the three classes of ionotropic glutamate receptors, kainate receptors (KARs) display a categorical brain distribution, which has been historically defined by 3H-radiolabeled kainate binding. Compared with recombinant KARs expressed in heterologous cells, synaptic KARs exhibit characteristically slow rise-time and decay kinetics. However, the mechanisms responsible for these unique KAR properties remain unclear. Here we found that both the distinct high affinity biding pattern in the mouse brain and the channel properties of native KARs are determined by the KAR auxiliary subunit Neto1. Through modulation of agonist binding affinity and off-kinetics of KARs, but not trafficking of KARs, Neto1 determines both KAR high affinity binding pattern and the distinctively slow kinetics of postsynaptic KARs. By regulating KAR-EPSC kinetics, Neto1 can control synaptic temporal summation, spike generation and fidelity. 2011-05-29 /pmc/articles/PMC3125417/ /pubmed/21623363 http://dx.doi.org/10.1038/nn.2837 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Straub, Christoph Hunt, David L. Yamasaki, Miwako Kim, Kwang S. Watanabe, Masahiko Castillo, Pablo E. Tomita, Susumu
spellingShingle	Straub, Christoph Hunt, David L. Yamasaki, Miwako Kim, Kwang S. Watanabe, Masahiko Castillo, Pablo E. Tomita, Susumu Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1
author_facet	Straub, Christoph Hunt, David L. Yamasaki, Miwako Kim, Kwang S. Watanabe, Masahiko Castillo, Pablo E. Tomita, Susumu
author_sort	Straub, Christoph
title	Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1
title_short	Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1
title_full	Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1
title_fullStr	Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1
title_full_unstemmed	Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1
title_sort	unique functions of kainate receptors in the brain are determined by the auxiliary subunit neto1
description	Ionotropic glutamate receptors principally mediate fast excitatory transmission in the brain. Among the three classes of ionotropic glutamate receptors, kainate receptors (KARs) display a categorical brain distribution, which has been historically defined by 3H-radiolabeled kainate binding. Compared with recombinant KARs expressed in heterologous cells, synaptic KARs exhibit characteristically slow rise-time and decay kinetics. However, the mechanisms responsible for these unique KAR properties remain unclear. Here we found that both the distinct high affinity biding pattern in the mouse brain and the channel properties of native KARs are determined by the KAR auxiliary subunit Neto1. Through modulation of agonist binding affinity and off-kinetics of KARs, but not trafficking of KARs, Neto1 determines both KAR high affinity binding pattern and the distinctively slow kinetics of postsynaptic KARs. By regulating KAR-EPSC kinetics, Neto1 can control synaptic temporal summation, spike generation and fidelity.
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125417/
_version_	1611462846498996224

Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1

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