Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design

Although the concept of Reverse Vaccinology was first pioneered for sepsis and meningococcal meningitidis causing bacterium, Neisseria meningitides, no broadly effective vaccine against serogroup B meningococcal disease is yet available. In the present investigation, HLA distribution analysis was un...

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Main Authors:	Misra, Namrata, Panda, Prasanna Kumar, Shah, Kavita, Sukla, Lala Bihari, Chaubey, Priyanka
Format:	Online
Language:	English
Published:	Biomedical Informatics 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124689/

id	pubmed-3124689
recordtype	oai_dc
spelling	pubmed-31246892011-07-07 Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design Misra, Namrata Panda, Prasanna Kumar Shah, Kavita Sukla, Lala Bihari Chaubey, Priyanka Hypothesis Although the concept of Reverse Vaccinology was first pioneered for sepsis and meningococcal meningitidis causing bacterium, Neisseria meningitides, no broadly effective vaccine against serogroup B meningococcal disease is yet available. In the present investigation, HLA distribution analysis was undertaken to select three most promiscuous T-cell epitopes out of ten computationally validated epitopes of Iron acquisition proteins from Neisseria MC58 by using the population coverage tool of Immune Epitope Database (IEDB). These epitopes have been determined on the basis of their binding ability with maximum number of HLA alleles along with highest population coverage rate values for all the geographical areas studied. The comparative population coverage analysis of moderately immunogenic and high immunogenic peptides suggests that the former may activate T-cell response in a fairly large proportion of people in most geographical areas, thus indicating their potential for development of epitope-based vaccine. Biomedical Informatics 2011-06-23 /pmc/articles/PMC3124689/ /pubmed/21738325 Text en © 2011 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Misra, Namrata Panda, Prasanna Kumar Shah, Kavita Sukla, Lala Bihari Chaubey, Priyanka
spellingShingle	Misra, Namrata Panda, Prasanna Kumar Shah, Kavita Sukla, Lala Bihari Chaubey, Priyanka Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design
author_facet	Misra, Namrata Panda, Prasanna Kumar Shah, Kavita Sukla, Lala Bihari Chaubey, Priyanka
author_sort	Misra, Namrata
title	Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design
title_short	Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design
title_full	Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design
title_fullStr	Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design
title_full_unstemmed	Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design
title_sort	population coverage analysis of t-cell epitopes of neisseria meningitidis serogroup b from iron acquisition proteins for vaccine design
description	Although the concept of Reverse Vaccinology was first pioneered for sepsis and meningococcal meningitidis causing bacterium, Neisseria meningitides, no broadly effective vaccine against serogroup B meningococcal disease is yet available. In the present investigation, HLA distribution analysis was undertaken to select three most promiscuous T-cell epitopes out of ten computationally validated epitopes of Iron acquisition proteins from Neisseria MC58 by using the population coverage tool of Immune Epitope Database (IEDB). These epitopes have been determined on the basis of their binding ability with maximum number of HLA alleles along with highest population coverage rate values for all the geographical areas studied. The comparative population coverage analysis of moderately immunogenic and high immunogenic peptides suggests that the former may activate T-cell response in a fairly large proportion of people in most geographical areas, thus indicating their potential for development of epitope-based vaccine.
publisher	Biomedical Informatics
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124689/
_version_	1611462547569901568

Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design

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