Serum 25-Hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men
The association between vitamin D levels and incident fractures in older men is uncertain. To test the hypothesis that low serum 25-hydroxyvitamin D [(25(OH)D] levels are associated with an increased risk of fracture, we performed a case-cohort study of 436 men with incident nonspine fractures, incl...
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| Language: | English |
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Wiley Subscription Services, Inc., A Wiley Company
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121172/ |
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pubmed-31211722011-06-23 Serum 25-Hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men Cauley, Jane A Parimi, Neeta Ensrud, Kristine E Bauer, Douglas C Cawthon, Peggy M Cummings, Steven R Hoffman, Andrew R Shikany, James M Barrett-Connor, Elizabeth Orwoll, Eric Original Article The association between vitamin D levels and incident fractures in older men is uncertain. To test the hypothesis that low serum 25-hydroxyvitamin D [(25(OH)D] levels are associated with an increased risk of fracture, we performed a case-cohort study of 436 men with incident nonspine fractures, including 81 hip fractures, and a random subcohort of 1608 men; average follow-up time 5.3 years. Serum vitamin D2 and vitamin D3 were measured on baseline sera using mass spectrometry and summed for total vitamin D. Modified Cox proportional hazards models were used to estimate the hazard ratio (HR) of fracture with 95% confidence intervals (CIs). Multivariable models included age, clinic, season, race, height, weight, and physical activity. The mean (SD) total 25(OH)D was 24.6 (7.8) ng/mL in nonspine fracture subjects, 21.5 (7.9) ng/mL in hip fracture subjects, and 25.2 (7.8) ng/mL in controls (nonspine fracture subjects versus nonpatients, p = .14; hip fracture subjects versus controls, p < .0001). 25(OH)D levels were unrelated to nonspine fractures. One SD decrease in total 25(OH)D was associated with an increased risk of hip fracture (multivariate HR = 1.60; 95% CI 1.18–2.17). Compared with men in the top quartile of total 25(OH)D (≥28), the HR of hip fracture was 2.36 (95% CI 1.08–5.15) for men in the lowest quartile (<20) (p = .009 for trend). Adjusting for hip bone mineral density attenuated the association by more than 50% (p = .065 for trend). Low serum 25(OH)D concentrations are associated with a higher risk of hip fracture in older men. Measurement of 25(OH)D may be useful in identifying men at high risk of hip fracture. © 2010 American Society for Bone and Mineral Research. Wiley Subscription Services, Inc., A Wiley Company 2010-03 2009-08-31 /pmc/articles/PMC3121172/ /pubmed/19775201 http://dx.doi.org/10.1359/jbmr.090826 Text en Copyright © 2010 American Society for Bone and Mineral Research http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Cauley, Jane A Parimi, Neeta Ensrud, Kristine E Bauer, Douglas C Cawthon, Peggy M Cummings, Steven R Hoffman, Andrew R Shikany, James M Barrett-Connor, Elizabeth Orwoll, Eric |
| spellingShingle |
Cauley, Jane A Parimi, Neeta Ensrud, Kristine E Bauer, Douglas C Cawthon, Peggy M Cummings, Steven R Hoffman, Andrew R Shikany, James M Barrett-Connor, Elizabeth Orwoll, Eric Serum 25-Hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men |
| author_facet |
Cauley, Jane A Parimi, Neeta Ensrud, Kristine E Bauer, Douglas C Cawthon, Peggy M Cummings, Steven R Hoffman, Andrew R Shikany, James M Barrett-Connor, Elizabeth Orwoll, Eric |
| author_sort |
Cauley, Jane A |
| title |
Serum 25-Hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men |
| title_short |
Serum 25-Hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men |
| title_full |
Serum 25-Hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men |
| title_fullStr |
Serum 25-Hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men |
| title_full_unstemmed |
Serum 25-Hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men |
| title_sort |
serum 25-hydroxyvitamin d and the risk of hip and nonspine fractures in older men |
| description |
The association between vitamin D levels and incident fractures in older men is uncertain. To test the hypothesis that low serum 25-hydroxyvitamin D [(25(OH)D] levels are associated with an increased risk of fracture, we performed a case-cohort study of 436 men with incident nonspine fractures, including 81 hip fractures, and a random subcohort of 1608 men; average follow-up time 5.3 years. Serum vitamin D2 and vitamin D3 were measured on baseline sera using mass spectrometry and summed for total vitamin D. Modified Cox proportional hazards models were used to estimate the hazard ratio (HR) of fracture with 95% confidence intervals (CIs). Multivariable models included age, clinic, season, race, height, weight, and physical activity. The mean (SD) total 25(OH)D was 24.6 (7.8) ng/mL in nonspine fracture subjects, 21.5 (7.9) ng/mL in hip fracture subjects, and 25.2 (7.8) ng/mL in controls (nonspine fracture subjects versus nonpatients, p = .14; hip fracture subjects versus controls, p < .0001). 25(OH)D levels were unrelated to nonspine fractures. One SD decrease in total 25(OH)D was associated with an increased risk of hip fracture (multivariate HR = 1.60; 95% CI 1.18–2.17). Compared with men in the top quartile of total 25(OH)D (≥28), the HR of hip fracture was 2.36 (95% CI 1.08–5.15) for men in the lowest quartile (<20) (p = .009 for trend). Adjusting for hip bone mineral density attenuated the association by more than 50% (p = .065 for trend). Low serum 25(OH)D concentrations are associated with a higher risk of hip fracture in older men. Measurement of 25(OH)D may be useful in identifying men at high risk of hip fracture. © 2010 American Society for Bone and Mineral Research. |
| publisher |
Wiley Subscription Services, Inc., A Wiley Company |
| publishDate |
2010 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121172/ |
| _version_ |
1611461668637769728 |