Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells
IL-10-producing CD4+ type 1 regulatory T (Tr1) cells, defined based on their ability to produce high levels of IL-10 in the absence of IL-4, are major players in the induction and maintenance of peripheral tolerance. Tr1 cells inhibit T-cell responses mainly via cytokine-dependent mechanisms. The ce...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
WILEY-VCH Verlag
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116154/ |