Revisiting gap locations in amino acid sequence alignments and a proposal for a method to improve them by introducing solvent accessibility
In comparative modeling, the quality of amino acid sequence alignment still constitutes a major bottleneck in the generation of high quality models of protein three-dimensional (3D) structures. Substantial efforts have been made to improve alignment quality by revising the substitution matrix, intro...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110861/ |