RyRCa2+ Leak Limits Cardiac Ca2+ Window Current Overcoming the Tonic Effect of Calmodulin in Mice

RyRCa2+ Leak Limits Cardiac Ca2+ Window Current Overcoming the Tonic Effect of Calmodulin in Mice

Ca2+ mediates the functional coupling between L-type Ca2+ channel (LTCC) and sarcoplasmic reticulum (SR) Ca2+ release channel (ryanodine receptor, RyR), participating in key pathophysiological processes. This crosstalk manifests as the orthograde Ca2+-induced Ca2+-release (CICR) mechanism triggered...

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Bibliographic Details
Main Authors: Fernández-Velasco, María, Ruiz-Hurtado, Gema, Rueda, Angélica, Neco, Patricia, Mercado-Morales, Martha, Delgado, Carmen, Napolitano, Carlo, Priori, Silvia G., Richard, Sylvain, María Gómez, Ana, Benitah, Jean-Pierre
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108979/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108979/

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