The Requirement for Pre-TCR during Thymic Differentiation Enforces a Developmental Pause That Is Essential for V-DJβ Rearrangement

The Requirement for Pre-TCR during Thymic Differentiation Enforces a Developmental Pause That Is Essential for V-DJβ Rearrangement

T cell development occurs in the thymus and is critically dependent on productive TCRβ rearrangement and pre-TCR expression in DN3 cells. The requirement for pre-TCR expression results in the arrest of thymocytes at the DN3 stage (β checkpoint), which is uniquely permissive for V-DJβ recombination;...

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Bibliographic Details
Main Authors: Hathcock, Karen S., Farrington, Lila, Ivanova, Irina, Livak, Ferenc, Selimyan, Roza, Sen, Ranjan, Williams, Joy, Tai, Xuguang, Hodes, Richard J.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108609/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108609/

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