Fine Needle Aspiration Cytology of the Breast: The Nonmalignant Categories

Currently, accurate diagnosis of breast lesions depends on a triple assessment approach comprising clinical, imaging and pathologic examinations. Fine needle aspiration cytology (FNAC) is widely adopted for the pathologic assessment because of its accurracy and ease of use. While much has been writt...

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Main Authors:	Mendoza, Paulo, Lacambra, Maribel, Tan, Puay-Hoon, Tse, Gary M.
Format:	Online
Language:	English
Published:	SAGE-Hindawi Access to Research 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108472/

id	pubmed-3108472
recordtype	oai_dc
spelling	pubmed-31084722011-06-09 Fine Needle Aspiration Cytology of the Breast: The Nonmalignant Categories Mendoza, Paulo Lacambra, Maribel Tan, Puay-Hoon Tse, Gary M. Review Article Currently, accurate diagnosis of breast lesions depends on a triple assessment approach comprising clinical, imaging and pathologic examinations. Fine needle aspiration cytology (FNAC) is widely adopted for the pathologic assessment because of its accurracy and ease of use. While much has been written about the atypical and maliganant categories of FNAC diagnosis, little covers the non-malignanat category which represents a sheer number in all FNAC cases. Moreover, any false-negative diagnosis of the non-malignant cases may lead to missed diagnosis of cancer. This paper aims to discuss the issues of smear adequacy, the cytologic features of benign breast lesions and the dilemma of a false-negative aspirate. Much has been suggested about the smear adequacy criterion, including quantifying epithelial clusters, whereas others advocate basing adequacy on qualitative quantum of using noncellular features of FNAC. Various benign lesions could be easily diagnosed at FNAC; however, they have cytologic features overlapped with malignant lesions. False negativity of FNAC does occur; this could be caused by either “true” false-negative cases attributed to suboptimal sampling technique, poor localization of the mass or nonpalpable lesions or “false” false-negative cases due to interpretational errors. Though false-positive cases are less commonly found, they will also be discussed briefly. SAGE-Hindawi Access to Research 2011-05-19 /pmc/articles/PMC3108472/ /pubmed/21660275 http://dx.doi.org/10.4061/2011/547580 Text en Copyright © 2011 Paulo Mendoza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Mendoza, Paulo Lacambra, Maribel Tan, Puay-Hoon Tse, Gary M.
spellingShingle	Mendoza, Paulo Lacambra, Maribel Tan, Puay-Hoon Tse, Gary M. Fine Needle Aspiration Cytology of the Breast: The Nonmalignant Categories
author_facet	Mendoza, Paulo Lacambra, Maribel Tan, Puay-Hoon Tse, Gary M.
author_sort	Mendoza, Paulo
title	Fine Needle Aspiration Cytology of the Breast: The Nonmalignant Categories
title_short	Fine Needle Aspiration Cytology of the Breast: The Nonmalignant Categories
title_full	Fine Needle Aspiration Cytology of the Breast: The Nonmalignant Categories
title_fullStr	Fine Needle Aspiration Cytology of the Breast: The Nonmalignant Categories
title_full_unstemmed	Fine Needle Aspiration Cytology of the Breast: The Nonmalignant Categories
title_sort	fine needle aspiration cytology of the breast: the nonmalignant categories
description	Currently, accurate diagnosis of breast lesions depends on a triple assessment approach comprising clinical, imaging and pathologic examinations. Fine needle aspiration cytology (FNAC) is widely adopted for the pathologic assessment because of its accurracy and ease of use. While much has been written about the atypical and maliganant categories of FNAC diagnosis, little covers the non-malignanat category which represents a sheer number in all FNAC cases. Moreover, any false-negative diagnosis of the non-malignant cases may lead to missed diagnosis of cancer. This paper aims to discuss the issues of smear adequacy, the cytologic features of benign breast lesions and the dilemma of a false-negative aspirate. Much has been suggested about the smear adequacy criterion, including quantifying epithelial clusters, whereas others advocate basing adequacy on qualitative quantum of using noncellular features of FNAC. Various benign lesions could be easily diagnosed at FNAC; however, they have cytologic features overlapped with malignant lesions. False negativity of FNAC does occur; this could be caused by either “true” false-negative cases attributed to suboptimal sampling technique, poor localization of the mass or nonpalpable lesions or “false” false-negative cases due to interpretational errors. Though false-positive cases are less commonly found, they will also be discussed briefly.
publisher	SAGE-Hindawi Access to Research
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108472/
_version_	1611457603700785152

Fine Needle Aspiration Cytology of the Breast: The Nonmalignant Categories

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