Structural basis for the recognition and cleavage of histone H3 by cathepsin L
Proteolysis of eukaryotic histone tails has emerged as an important factor in the modulation of cell-cycle progression and cellular differentiation. The recruitment of lysosomal cathepsin L to the nucleus where it mediates proteolysis of the mouse histone H3 tail has been described recently. Here, w...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105313/ |